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Results: 5

1.
Fig. 2

Fig. 2. From: LIN28A immunoreactivity is a potent diagnostic marker of embryonal tumor with multilayered rosettes (ETMR).

Expression of LIN28A strongly and significantly correlates with expression of HMGA2 (a), MYCN (b), CDK6 (c), and NRAS in ETMR (d)

Andrey Korshunov, et al. Acta Neuropathol. 2012 December;124(6):875-881.
2.
Fig. 5

Fig. 5. From: LIN28A immunoreactivity is a potent diagnostic marker of embryonal tumor with multilayered rosettes (ETMR).

Kaplan-Meier overall survival analysis for LIN28A positive malignant brain tumors versus LIN28A negative malignant brain tumors in children. Overall 5-year survival was 0 % for LIN28A positive versus 68 % for LIN28A negative tumors (log-rank, p < 0.001). Numbers on the Y-axis indicate the fraction of surviving patients. Numbers on the X axis indicate the follow-up time in years

Andrey Korshunov, et al. Acta Neuropathol. 2012 December;124(6):875-881.
3.
Fig. 4

Fig. 4. From: LIN28A immunoreactivity is a potent diagnostic marker of embryonal tumor with multilayered rosettes (ETMR).

LIN28A expression patterns in primary and recurrent ETMR. Primary ETMR with single multilayered rosettes and abundant neuropil (a). LIN28A expression is limited with rosettes and small cell collections (b). The ETMR relapse from the same patient is composed of hypercellular areas but lacks neuropil areas (c). Strong and diffuse LIN28A expression in all cells of the recurrent tumor (d)

Andrey Korshunov, et al. Acta Neuropathol. 2012 December;124(6):875-881.
4.
Fig. 1

Fig. 1. From: LIN28A immunoreactivity is a potent diagnostic marker of embryonal tumor with multilayered rosettes (ETMR).

LIN28A expression is highly upregulated only in ETMR cases when compared to other pediatric and adult brain tumors (n = 1404) and normal CNS and non-CNS tissues (n = 353). The numbers in parentheses indicate the number of samples for each entity. All data were generated on Affymetrix U133plus 2.0 arrays and were analysed using the microarray analysis and visualization platform R2 (http://r2.amc.nl)

Andrey Korshunov, et al. Acta Neuropathol. 2012 December;124(6):875-881.
5.
Fig. 3

Fig. 3. From: LIN28A immunoreactivity is a potent diagnostic marker of embryonal tumor with multilayered rosettes (ETMR).

LIN28A immunohistochemistry in pediatric malignant CNS tumors. Microscopic appearance of ETMR composed of clusters of multilayered rosettes embedded in abundant neuropil (initially diagnosed as ETANTR) (a). Intense LIN28A expression in poorly differentiated areas containing rosettes and the absence of expression in neuropil of tumor (b). Microscopic appearance of ETMR composed of numerous rosettes with clusters of small poorly differentiated cells (initially diagnosed as ependymoblastoma) (c). Strong and diffuse LIN28 expression in all parts of the tumor (d). AT/RT. Focal LIN28A expression in single collections of tumor cells (e). Anaplastic ependymoma. Immunonegativity for LIN28A in tumor region with numerous ependymal rosettes (f)

Andrey Korshunov, et al. Acta Neuropathol. 2012 December;124(6):875-881.

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