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1.
Figure 3

Figure 3. Detail of E2-suppressible genes in groups separated by clustering analysis.. From: Dose-Related Estrogen Effects on Gene Expression in Fetal Mouse Prostate Mesenchymal Cells.

Set 5: E2-suppressible high sensitivity. Set 6: E2-suppressible low sensitivity. The figures show raw p values as well as, where indicated, Benjamini-Hochberg corrected p values.

Julia A. Taylor, et al. PLoS One. 2012;7(10):e48311.
2.
Figure 5

Figure 5. Glucose metabolism pathway.. From: Dose-Related Estrogen Effects on Gene Expression in Fetal Mouse Prostate Mesenchymal Cells.

Highlighted genes (outlined in red) were influenced by lower dose estradiol treatment (10 pM and 100 pM) in an inverted U manner, suggesting enhancement of glycolysis by 10 pM E2 but suppression by 100 pM E2.

Julia A. Taylor, et al. PLoS One. 2012;7(10):e48311.
3.
Figure 2

Figure 2. Detail of E2-inducible genes in groups identified by clustering analysis.. From: Dose-Related Estrogen Effects on Gene Expression in Fetal Mouse Prostate Mesenchymal Cells.

Set 1: E2-inducible high sensitivity. Set 2: E2- inducible moderate sensitivity. Set 3: E2-inducible low sensitivity. Select genes of interest are highlighted. The figures show raw p values as well as, where indicated, Benjamini-Hochberg corrected p values.

Julia A. Taylor, et al. PLoS One. 2012;7(10):e48311.
4.
Figure 6

Figure 6. Comparison of expression of selected genes measured by microarray and by Q-PCR.. From: Dose-Related Estrogen Effects on Gene Expression in Fetal Mouse Prostate Mesenchymal Cells.

Gene expression in cells treated with 100 nM 17β-estradiol (grey bars) is compared to that in untreated control cells (black bars). * Control vs. treated cells statistically different, p<0.05. The qPCR data were previously published elsewhere [19].

Julia A. Taylor, et al. PLoS One. 2012;7(10):e48311.
5.
Figure 4

Figure 4. Detail of E2-suppressible genes in groups separated by clustering analysis.. From: Dose-Related Estrogen Effects on Gene Expression in Fetal Mouse Prostate Mesenchymal Cells.

A) Set 7: Inverted U-curve. Both raw p values and Benjamini-Hochberg corrected p values are given. B) Genes identified as part of the glucose metabolic pathway in panel A depicted as relative values to illustrate the high association between dose and gene expression.

Julia A. Taylor, et al. PLoS One. 2012;7(10):e48311.

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