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1.
Figure 6

Figure 6. From: PET/MRI for Neurological Applications.

Comparison of MRI time-to-peak (TTP) and PET OEF images in two patients measured in the chronic phase of stroke illustrating the mismatch-penumbra debate. Disagreement between the two techniques is observed in the first (upper row) and agreement in the second case (lower row). Figure reproduced from (80).

Ciprian Catana, et al. J Nucl Med. 2012 December;53(12):10.2967/jnumed.112.105346.
2.
Figure 4

Figure 4. From: PET/MRI for Neurological Applications.

Simultaneous PET/MR studies in patients with brain tumors. From left to right: axial MR, PET and fused images are shown for different tracers: FDG, FMISO, FLT (data acquired on the BrainPET prototype, Martinos Center, MGH) and FET (data acquired on the BrainPET prototype, Forschungszentrum Juelich, Germany; images courtesy of Hans Herzog, PhD and Karl-Josef Langen, MD).

Ciprian Catana, et al. J Nucl Med. 2012 December;53(12):10.2967/jnumed.112.105346.
3.
Figure 7

Figure 7. From: PET/MRI for Neurological Applications.

Simultaneous PET/MR study in an epilepsy patient. From left to right: Axial FDG-PET (60–75 min post-injection), high resolution MRI-scan and fusion image. Distinct hypometabolism is visible in the polar region of the left temporal lobe, typically corresponding to the epileptogenic focus. Data acquired on the Biograph mMR scanner, Munich.

Ciprian Catana, et al. J Nucl Med. 2012 December;53(12):10.2967/jnumed.112.105346.
4.
Figure 2

Figure 2. From: PET/MRI for Neurological Applications.

MRI-assisted PET motion correction in a healthy volunteer using EPI-derived motion estimates. Upper row: plots of motion estimates – translations along (black) and rotations about (gray) the three orthogonal axes. Lower row: PET data reconstructed before (left) and after (right) motion correction. Substantial improvement in image quality can be observed after correction. Data acquired on the BrainPET prototype, Martinos Center, MGH.

Ciprian Catana, et al. J Nucl Med. 2012 December;53(12):10.2967/jnumed.112.105346.
5.
Figure 5

Figure 5. From: PET/MRI for Neurological Applications.

Simultaneous PET/MR study in an AD patient. Upper row: axial FDG-PET, high resolution MRI and fusion image. Areas with reduced metabolism (green) representing impaired neuronal function are visible in the left temporo-parietal cortex. Lower rows: Surface projections of cerebral metabolism and of Z-scores images (comparison with controls). Data acquired on the Biograph mMR scanner, Munich.

Ciprian Catana, et al. J Nucl Med. 2012 December;53(12):10.2967/jnumed.112.105346.
6.
Figure 1

Figure 1. From: PET/MRI for Neurological Applications.

First simultaneous PET/MR study in a 66-year-old healthy volunteer. The MR sequences run included T2 turbo spin echo, EPI, time-of-flight MR-angiography and MRS. The PET image displayed was reconstructed from the twenty-minute emission data recorded at steady state after injection of 370 MBq of FDG. Data acquired on the BrainPET prototype, Siemens, Knoxville, TN. Reproduced with permission from (1).

Ciprian Catana, et al. J Nucl Med. 2012 December;53(12):10.2967/jnumed.112.105346.
7.
Figure 3

Figure 3. From: PET/MRI for Neurological Applications.

Influence of MR-based PVE correction on PET image contrast for a “normal” brain. From left to right, the MR image used to automatically segment ROIs of multiple brain structures, the original PET image, PVE correction factors for mean ROI values calculated via the geometric transfer matrix method using the segmented MR and original PET images as inputs, and the original PET image after application of the recovery coefficients. Data acquired on the BrainPET prototype, Martinos Center, MGH. Images courtesy of Spencer Bowen, PhD.

Ciprian Catana, et al. J Nucl Med. 2012 December;53(12):10.2967/jnumed.112.105346.

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