Results: 2

1.
Figure 1

Figure 1. From: Diagnostic Role of Chromosomal Instability in Melanoma.

Chromosomal abnormalities are prevalent in melanoma. Shown are pairs of representative karyotypes from 3 melanoma lines, DM1N, DM2N, and DM3N revealing heterogeneity between cells within the culture and overall increases (D1 and D3) and decreases in the total number of chromosomes (D2). Single cell clones from these lines will also expand in culture giving rise to cells with different karyotypes (data not shown) suggesting ongoing CIN.

Nitika Dabas, et al. J Skin Cancer. 2012;2012:914267.
2.
Figure 2

Figure 2. From: Diagnostic Role of Chromosomal Instability in Melanoma.

FISH utilizes fluorescent probes to specific areas on chromosomes in cultured cells. Illustrated are OligoFISH probes to the centromeres of chromosomes 2 (yellow), 6 (light blue), 7 (green), and 8 (red). (a) demonstrates the binding to specific chromosomes in a metaphase spread; (b), binding to DNA sequences in a normal diploid human cell, and (c), binding to sequences in a cell with an abnormally increased chromosomal number.

Nitika Dabas, et al. J Skin Cancer. 2012;2012:914267.

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