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Results: 3

1.
Figure 2

Figure 2. Interaction effect of COMT genotype and treatment arm on change in IBS-SSS.. From: Catechol-O-Methyltransferase val158met Polymorphism Predicts Placebo Effect in Irritable Bowel Syndrome.

The interaction between COMT genotype (number of met alleles) and treatment arm was statistically significant (beta = 0.17; p = .035). Regression model included the following parameters: COMT genotype (number of met alleles), treatment arm, baseline IBS-SSS and their interaction (COMT genotype x treatment arm). Error bars indicate the standard error of the mean. N = 104.

Kathryn T. Hall, et al. PLoS One. 2012;7(10):e48135.
2.
Figure 1

Figure 1. Effect of COMT genotype on change in IBS-SSS.. From: Catechol-O-Methyltransferase val158met Polymorphism Predicts Placebo Effect in Irritable Bowel Syndrome.

Number of val158met met alleles showed a significant linear effect on IBS-SSS (beta = 0.17; p = .032). IBS-SSS includes abdominal pain severity, abdominal pain frequency, abdominal distention severity, dissatisfaction with bowel habits, and disruption of quality of life. Change in IBS-SSS  =  (IBS-SSS at baseline – IBS-SSS at 3-weeks). Regression model included COMT genotype (number of met alleles) and baseline IBS-SSS. Error bars indicate the standard error of the mean. N = 104.

Kathryn T. Hall, et al. PLoS One. 2012;7(10):e48135.
3.
Figure 3

Figure 3. Interaction effect of COMT genotype and treatment arm on Adequate Relief.. From: Catechol-O-Methyltransferase val158met Polymorphism Predicts Placebo Effect in Irritable Bowel Syndrome.

The interaction (COMT genotype x treatment arm) was statistically significant (beta = 0.25; p = .009), but not COMT genotype (beta = 0.01; p = .954). Adequate Relief was assessed by a single dichotomous categorization at three weeks, which asked patients: “Over the past week have you had adequate relief of your IBS symptoms?” Regression model parameters included: COMT genotype (number of met alleles), treatment arm and their interaction (COMT genotype x treatment arm). Error bars are standard error of the mean. N = 102.

Kathryn T. Hall, et al. PLoS One. 2012;7(10):e48135.

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