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Results: 2

1.
Figure 1

Figure 1. From: Pivots of pluripotency: the roles of non-coding RNA in regulating embryonic and induced pluripotent stem cells.

Summary of known microRNAs that regulate Core pluripotency factors and the pluripotent state. Solid lines denote known direct regulation, and dashed lines indicate indirect or incompletely characterized mechanisms of regulation.

Jeffrey S. Huo, et al. Biochim Biophys Acta. ;1830(2):2385-2394.
2.
Figure 2

Figure 2. From: Pivots of pluripotency: the roles of non-coding RNA in regulating embryonic and induced pluripotent stem cells.

Summary of mechanisms of ncRNA regulation of gene expression identified in ESCs. (a) MiRNAs (green) can post-transcriptionally inhibit constellations of target mRNAs directly, (b) target mRNA for transcription factors (like Sox2, Oct4, or Klf4), or (c) target mRNA for epigenetic regulators (like Cbx7). (d) MiRNAs can also inhibit other miRNAs through Lin28 lncRNAs, (e) catalyze the assembly of specific genetic regulators into complexes for establishment or erasure of epigenetic states, or (f) inhibit the activity of other miRNAs by mechanisms such as sequestration of target miRNA (linc-MD1), targeting of mRNA degradation, or enhancement of transcription (not shown). Additional mechanisms of genetic regulation by ncRNAs observed in other cell lines may ultimately also be identified in stem cells.

Jeffrey S. Huo, et al. Biochim Biophys Acta. ;1830(2):2385-2394.

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