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Results: 5

1.
Figure 2

Figure 2. From: Spatial Memory Deficits and Motor Coordination Facilitation in cGMP-Dependent Protein Kinase Type II-deficient Mice.

The Rotating Rod Test. The averages (±SEM) for time spent on the Rotating Rod Test across eight trials (four trials per day for two days) for WT, n=13, (dashed line) and KO, n=14 (solid line) animals.

Charlotte M. Wincott, et al. Neurobiol Learn Mem. ;99:32-37.
2.
Figure 5

Figure 5. From: Spatial Memory Deficits and Motor Coordination Facilitation in cGMP-Dependent Protein Kinase Type II-deficient Mice.

Immunoblot analysis of the PSD from hippocampus and PFC in WT and KO animals. (A) Representative immunoblots of the PSD of hippocampus and PFC in WT and KO animals (n=3 animals, duplicated). (B) Presented is the average (± SEM) of normalized intensity of hippocampal GluA1 S845 phosphorylation in WT (white bar) and KO (black bar). (C) Presented is the average (± SEM) of normalized intensity of PFC GluA1 S845 phosphorylation in WT (white bar) and KO (black bar).

Charlotte M. Wincott, et al. Neurobiol Learn Mem. ;99:32-37.
3.
Figure 1

Figure 1. From: Spatial Memory Deficits and Motor Coordination Facilitation in cGMP-Dependent Protein Kinase Type II-deficient Mice.

(A) Acoustic startle response to 120 db stimulus. Data are the average (±SEM) for wild type (WT), n=13 (white bar) and knockout cGKII (KO), n=14 (black bar). (B) Prepulse inhibition (PPI) to acoustic startle response. The averages (±SEM) for levels (%) of PPI of the startle response in WT (black dotted line) and KO (black solid line).

Charlotte M. Wincott, et al. Neurobiol Learn Mem. ;99:32-37.
4.
Figure 3

Figure 3. From: Spatial Memory Deficits and Motor Coordination Facilitation in cGMP-Dependent Protein Kinase Type II-deficient Mice.

Open field exploration. (A) Vertical activity in open field assay. Data are the average (±SEM) for wild type (WT), n=13, (white bar) and knockout cGKII (KO), n=14 (black bar) animals. (B) Total distance travelled. Data are the average in centimenters (±SEM) for WT, n=13, (white bar) and KO, n=14 (black bar) animals. (C) Center to total time ratio. Data are the average (±SEM) for WT, n=13, (white bar) and KO, n=14 (black bar) animals.

Charlotte M. Wincott, et al. Neurobiol Learn Mem. ;99:32-37.
5.
Figure 4

Figure 4. From: Spatial Memory Deficits and Motor Coordination Facilitation in cGMP-Dependent Protein Kinase Type II-deficient Mice.

Spatial learning in the Morris Water Maze. (A) Across 10 days, presented is the average (±SEM) latency (seconds) to locate the platform for wild type (WT), n=12, (dashed line) and cGKII knockout (KO), n=10 (solid line) animals. Days 1–5 of acquisition, the platform is hidden, Days 1–3 – Rev indicate latency to find the hidden platform during the reversal trials, and Days 1–2 – Vis indicate the latency to find the visible platform. (B) Presented is the average (±SEM) time spent in seconds during the probe trial in each quadrant for WT (white bar) and cGKII KO (black bar) animals. TQ = target quadrant, AR = adjacent right quadrant, OP = opposite quadrant, and AL = adjacent left quadrant. (C) Presented is the average (±SEM) number of platform crossings during the probe trial in WT (white bar) and cGKII KO animals (black bar).

Charlotte M. Wincott, et al. Neurobiol Learn Mem. ;99:32-37.

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