FIG. 1.

FIG. 1. From: The Role of DNA Methylation in Aging, Rejuvenation, and Age-Related Disease.

Schematic representation of the changes in the methylome during aging. Purple circles are indicative of methylated CpG dinucleotides. Aging is often marked by the establishment of global hypomethylation and regions of CpG island hypermethylation. These changes in the epigenetic landscape may contribute to aging by adversely affecting genomic stability and gene regulation. (Color image is available at

Adiv A. Johnson, et al. Rejuvenation Res. 2012 October;15(5):483-494.

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