Figure 1

Figure 1. Vegfa produced by RPE cells is required for maintenance of the subretinal vasculature and cone photoreceptors in mice.. From: Turning a blind eye to anti-VEGF toxicities.

(A) In the adult eye, retinal pigment epithelial cells produce Vegfa, which is required for maintenance of the fenestrated choriocapillaris. (B) Following RPE-specific deletion of the Vegfa gene from adult mice, the choriocapillaris rapidly disappears and is associated with death of cone photoreceptors required for central and color vision. In contrast, the rod photoreceptors are not damaged.

Susan E. Quaggin. J Clin Invest. 2012 November 1;122(11):3849-3851.

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