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Results: 5

1.
Figure 5

Figure 5. From: MCP-1-Induced Histamine Release from Mast Cells Is Associated with Development of Interstitial Cystitis/Bladder Pain Syndrome in Rat Models.

LPS-stimulated MCP-1 release from bladder epithelial cells in a dose- and time-dependent manner (a). MCP-1 induced histamine release from MCs (b). MCP-1 and histamine in the supernatant of bladder epithelial cells and mast cells were detected with ELISA (n = 3).

Jianwei Lv, et al. Mediators Inflamm. 2012;2012:358184.
2.
Figure 4

Figure 4. From: MCP-1-Induced Histamine Release from Mast Cells Is Associated with Development of Interstitial Cystitis/Bladder Pain Syndrome in Rat Models.

LPS-induced CCR2 receptor expression in bladder tissues. (a) and (c) Control group; (b) and (d) LPS group. CCR2 receptors were detected with immunohistochemistry ((a) and (b) ×40; (c) and (d) ×400). (e) LPS-increased CCR2 receptor expression on the surface of mast cells detected by flow cytometry.

Jianwei Lv, et al. Mediators Inflamm. 2012;2012:358184.
3.
Figure 2

Figure 2. From: MCP-1-Induced Histamine Release from Mast Cells Is Associated with Development of Interstitial Cystitis/Bladder Pain Syndrome in Rat Models.

ELISA results for histamine analysis. (a) Histamine levels in bladder tissues of the Model group (n = 6) show no significant difference with those of the Control group (n = 3) (P = 0.796). (b) Histamine levels were significantly elevated in urine from the Model group compared with the Control group (P < 0.05).

Jianwei Lv, et al. Mediators Inflamm. 2012;2012:358184.
4.
Figure 1

Figure 1. From: MCP-1-Induced Histamine Release from Mast Cells Is Associated with Development of Interstitial Cystitis/Bladder Pain Syndrome in Rat Models.

MCP-1 immunodetection. LPS-treated rats showed increased expression of MCP-1 in bladder tissues. (a) and (c) Control group (n = 3); (b) and (d) Model group (n = 6). ((a) and (b): ×40; (c) and (d): ×400). ELISA results indicate that MCP-1 levels in bladder tissue (e) and urine (f) from the Model group were elevated compared to levels observed in the Control group (P < 0.05).

Jianwei Lv, et al. Mediators Inflamm. 2012;2012:358184.
5.
Figure 3

Figure 3. From: MCP-1-Induced Histamine Release from Mast Cells Is Associated with Development of Interstitial Cystitis/Bladder Pain Syndrome in Rat Models.

LPS-induced degranulation of mast cells. (a) Control group (n = 3); (b) Model group (n = 6). The mast cells with or without degranulation are indicated with red or blue arrows, respectively. Double-labeled immunofluorescence microscopy showing MCP-1 interactions with mast cells in bladder tissues. (c) Control group (n = 3); (d) Model group (n = 6). Nuclei are colored blue by DAPI; green fluorescence indicates MCP-1 protein immunostaining; red fluorescence indicates MC immunostaining. Scale bars in the immunofluorescence images represent 20 μm.

Jianwei Lv, et al. Mediators Inflamm. 2012;2012:358184.

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