Results: 4

1.
Figure 2

Figure 2. From: Neuropathologic substrates of Parkinson’s disease dementia.

At the optimal cut points for the global cortical scores, CLBs/LNs have the highest sensitivity (74%; specificity 67%) for dementia, while NFTs and SPs have a higher specificity (75% and 86%, respectively; sensitivity 55% for both) ().

David J. Irwin, et al. Ann Neurol. ;72(4):587-598.
2.
Figure 3

Figure 3. From: Neuropathologic substrates of Parkinson’s disease dementia.

The stepwise-selection model building procedure identified two significant correlates of dementia: CLB/LN score (p<0.001, OR 4. 06, 95%CI 1.87–8.81) and APOE4 genotype carrier status (p= 0.018, OR 4.19, 95%CI 1.28–13.75; ). We found no significant interaction between these variables, and also between APOE4 genotype and measures of AD pathology or gender. The ROC curve obtained using this model () shows high diagnostic performance of the model (area under the curve= 80.7%).

David J. Irwin, et al. Ann Neurol. ;72(4):587-598.
3.
Figure 1

Figure 1. From: Neuropathologic substrates of Parkinson’s disease dementia.

A stepwise-selection model building procedure was used to develop a logistic regression model to examine the association of these variables with the primary outcome of dementia in this cohort. Individual cortical region scores, AGD, CAA and HpScl were excluded from the selection procedure due to limited data for these features in some groups, but were examined in the univariate analysis (, ). A receiver operating characteristic curve (ROC) was generated to assess the diagnostic accuracy of the model.

David J. Irwin, et al. Ann Neurol. ;72(4):587-598.
4.
Figure 4

Figure 4. From: Neuropathologic substrates of Parkinson’s disease dementia.

Some studies have suggested an exponential rate of clinical progression in PD, with older age of motor onset associated with a shorter MDI and higher burden of CLB/LN, SP and NFT pathology., Due to the large range in MDI in our cohort (2–30 years), we chose a similar stratification of the PDD group into short-(MDI <10 years) and long-MDI (MDI ≥10 years) groups to explore this phenomenon (). The short-MDI cases were mostly male (88%, p=0.013), older at PD onset (p<0.001) and had a shorter overall disease duration (p<0.001). Furthermore, they had higher levels of cortical NFTs (p=0.003) and CLBs/LNs (p=0.028) (), with a higher percentage (47.8%) of co-morbid AD (p=0.027).

David J. Irwin, et al. Ann Neurol. ;72(4):587-598.

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