Figure 1

Figure 1. From: Thalamocortical dysconnectivity in schizophrenia.

Resting-state functional connectivity between cortex and thalamus is altered in schizophrenia. The cortex is partitioned into six, non-overlapping regions-of-interest which were used as seeds in a functional connectivity analysis (panel A). Activity in each cortical region-of-interest correlated with distinct areas of the thalamus in both healthy subjects (panel B) and patients with schizophrenia (panel C). Comparison between groups revealed decreased prefrontal connectivity with the thalamus, and increased motor and somatosensory thalamic connectivity in schizophrenia (panel D). Images thresholded at p=.05 (cluster-wise corrected) for voxel-wise p=.001. We used a similar presentation format as Zhang et al. (14,15) and Fair et al. (23) to facilitate comparison of the current results with prior findings in healthy subjects.

Neil D. Woodward, et al. Am J Psychiatry. 2012 October;169(10):10.1176/appi.ajp.2012.12010056.

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