Results: 3

1.
Figure 2

Figure 2. From: Epigenetic Mechanisms and the Development of Asthma.

Effect of epigenetic marks – DNA methylation, histone modifications, and miRNAs – on gene expression. White circles denote unmethylated CpGs while black circles denote methylated CpGs. Green circles refer to permissive histone modifications while red circles indicate repressive histone marks. miRNAs can affect gene expression by either RNA degradation (perfect complementarity and binding) or inhibition of protein translation (imperfect complementarity and partial binding).

Ivana V. Yang, et al. J Allergy Clin Immunol. ;130(6):1243-1255.
2.
Figure 3

Figure 3. From: Epigenetic Mechanisms and the Development of Asthma.

An overview of the validation process for discovery of epigenetic marks associated with development of asthma. Internal validation refers to confirmation in the same cohort by a different technique and association of epigenetic marks with changes in gene expression while external validation refers to validation of epigenetic marks in an independent cohort. Genome-wide analysis of gene expression is preferable to focused approaches due to complexities in the relationship of epigenetic marks and gene expression alterations.

Ivana V. Yang, et al. J Allergy Clin Immunol. ;130(6):1243-1255.
3.
Figure 1

Figure 1. From: Epigenetic Mechanisms and the Development of Asthma.

An overview of epigenetic regulation of gene expression in asthma. Environmental exposures and dietary factors an individual is exposed to both in utero and postnatally influence epigenetic marks which in turns regulates genes expression. Underlying genetic variation can regulate gene expression by affecting epigenetic marks or by other mechanisms (alteration of transcription factor binding sites, for example). Alterations in epigenetic marks have consequences on expression of key immune genes that regulate Th subtype cell skewing, which in turn leads to development of disease. It is likely that distinct epigenomic profiles are associated with the development of allergic and non-allergic forms of asthma.

Ivana V. Yang, et al. J Allergy Clin Immunol. ;130(6):1243-1255.

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