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Results: 4

1.
Figure 4

Figure 4. Hazard ratios for all-cause mortality according to eGFR in participants with and without diabetes in individuals with and without hypertension from the general population and high-risk cohorts. From: Associations of kidney disease measures with mortality and end-stage renal disease in individuals with and without diabetes: a meta-analysis.

(A, B) Individuals with hypertension. (C, D) Individuals without hypertension. Blue and red circles denote p<0·05 as compared with the reference (diamond). Significant interaction between diabetes and eGFR is shown by x signs. Hazard ratios were adjusted for age, sex, race, smoking, history of cardiovascular disease, serum total cholesterol concentration, body-mass index, and albuminuria (log albumin-to-creatinine ratio, log protein-to-creatinine, or categorical dipstick proteinuria [negative, trace, 1+, ≥2+])

Caroline S Fox, et al. Lancet. 2012 November 10;380(9854):1662-1673.
2.
Figure 2

Figure 2. Hazard ratios for all-cause and cardiovascular mortality in the combined general and high-risk populations according to ACR in participants with and without diabetes. From: Associations of kidney disease measures with mortality and end-stage renal disease in individuals with and without diabetes: a meta-analysis.

(A, B) All-cause mortality. (C, D) Cardiovascular mortality. Panels A and C use one reference point (diamond, ACR of 5 mg/g in the no diabetes group), for both individuals with and without hypertension to show the main effect of diabetes on risk. Panels B and D use separate references (diamonds) in the diabetes and no diabetes groups to assess interaction with diabetes specifically. Hazard ratios were adjusted for age, sex, race, smoking, history of cardiovascular disease, serum total cholesterol concentration, body-mass index, and estimated glomerular filtration rate. Blue and red circles denote p<0·05 as compared with the reference (diamond). Significant interaction between diabetes and ACR is shown by x signs. ACR=albumin-to-creatinine ratio.

Caroline S Fox, et al. Lancet. 2012 November 10;380(9854):1662-1673.
3.
Figure 3

Figure 3. Hazard ratios for end-stage renal disease in the chronic kidney disease populations according to eGFR and ACR in participants with and without diabetes. From: Associations of kidney disease measures with mortality and end-stage renal disease in individuals with and without diabetes: a meta-analysis.

(A, B) eGFR. (C, D) ACR. Panels A and C use eGFR of 50 mL/min per 1·73 m2 (A) and ACR of 20 mg/g (C) in individuals without diabetes as the reference point (diamond) for both individuals with and without diabetes. Panels B and D use eGFR of 50 mL/min per 1·73 m2 (B) and ACR of 20 mg/g (D) as the reference points (diamond) in diabetic and non-diabetic groups. Blue and red circles denote p<0·05 as compared with the reference (diamond). Hazard ratios were adjusted for age, sex, race, smoking, history of cardiovascular disease, serum total cholesterol concentration, body-mass index, and albuminuria (log albumin-to-creatinine ratio, log protein-to-creatinine, or categorical dipstick proteinuria [negative/ trace, 1+, 2+, ≥3+]) or eGFR. eGFR=estimated glomerular filtration rate. ACR=albumin-to-creatinine ratio.

Caroline S Fox, et al. Lancet. 2012 November 10;380(9854):1662-1673.
4.
Figure 1

Figure 1. Hazard ratios for all-cause and cardiovascular mortality in the combined general and high-risk populations according to eGFR in individuals with and without diabetes. From: Associations of kidney disease measures with mortality and end-stage renal disease in individuals with and without diabetes: a meta-analysis.

(A, B) All-cause mortality. (C, D) Cardiovascular mortality. Panels A and C use one reference point (diamond, eGFR of 95 mL/min per 1·73 m2 in the no diabetes group) for both individuals with and without diabetes to show the main effect of diabetes on risk. Panels B and D use separate references (diamonds) in the diabetes and no diabetes groups to assess interaction with diabetes specifically. Hazard ratios were adjusted for age, sex, race, smoking, history of cardiovascular disease, serum total cholesterol concentration, body-mass index, and albuminuria (log albumin-to-creatinine ratio, log protein-to-creatinine, or categorical dipstick proteinuria [negative, trace, 1+, ≥2+]). Blue and red circles denote p<0·05 as compared with the reference (diamond). Significant interaction between diabetes and eGFR is shown by x signs. eGFR=estimated glomerular filtration rate.

Caroline S Fox, et al. Lancet. 2012 November 10;380(9854):1662-1673.

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