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Results: 2

1.
Figure 1

Figure 1. From: The Effects of Vertical Sleeve Gastrectomy in Rodents Are Ghrelin Independent.

A significant effect of surgery was observed in (A) acyl and (B) desacyl (P < .001) ghrelin levels collected from VSG (n = 7), RYGB (n = 4), pair-fed (n = 10), and sham-operated rats (n = 10) at different times during postoperative days 68–72 (P < .05). Circulating levels of acyl and desacyl ghrelin were reduced significantly compared with values in sham-operated rats (*P < .05), pair-fed ($P < .05), and RYGB (#P< .05) animals (Bonferroni multiple comparisons tests). Ad lib, ad libitum.

ADAM P. CHAMBERS, et al. Gastroenterology. ;144(1):50-52.e5.
2.
Figure 2

Figure 2. From: The Effects of Vertical Sleeve Gastrectomy in Rodents Are Ghrelin Independent.

Metabolic effects of VSG in ghrelin KO (n = 10) and wild-type (WT) (n = 9) mice relative to sham-operated mice (n = 7 of 7). (A) Ghrelin deficiency was confirmed in KO mice using a commercially available enzyme-linked immunosorbent assay for total ghrelin (*P < .05). (B) Cumulative food intake 45 days after surgery and (C) body weight were reduced by VSG relative to sham-operated mice in both genotypes (*P < .05). (D) Body composition data measured on postoperative day 42 show reductions in fat mass in VSG compared with sham mice (*P < .05), with no effect on lean mass (P > .05). (E) A mixed-meal tolerance test on postoperative day 28 shows improvements in oral glucose tolerance in VSG mice relative to sham-operated mice (*P < .05). (F) Food selection test shows VSG mice ate more calories in the form of carbohydrates and fewer calories from fat than sham-operated mice (*P < .05) (Bonferroni multiple comparisons tests).

ADAM P. CHAMBERS, et al. Gastroenterology. ;144(1):50-52.e5.

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