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1.
Figure 1

Figure 1. From: The t(4;14) translocation and FGFR3 overexpression in multiple myeloma: prognostic implications and current clinical strategies.

Chromosomal regions affected by the t(4;14) translocation. Schematic representations of the regions of chromosomes 4 and 14 that are involved in the t(4;14) translocation.

A Kalff, et al. Blood Cancer J. 2012 September;2(9):e89.
2.
Figure 2

Figure 2. From: The t(4;14) translocation and FGFR3 overexpression in multiple myeloma: prognostic implications and current clinical strategies.

The FGFR and downstream pathways. Signaling pathways activated by FGF ligand binding to FGFR include the mitogen-activated protein kinase (RAS-RAF-MAPK), phosphatidylinositol 3-kinase (PI3K-AKT-mTOR), phospholipase Cγ (PLCγ), protein kinase C (PKC), and signal transducer and activator of transcription (STAT) pathways. DAG, diacylglycerol; FGF, fibroblast growth factor; FGFR, fibroblast growth factor receptor; JAK, Janus kinase.

A Kalff, et al. Blood Cancer J. 2012 September;2(9):e89.

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