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Figure 1

Figure 1. Association results, recombination, and linkage disequilibrium plots for the region of 10q23 with genome-wide significance for gastric cancer (GC) and esophageal squamous cell carcinoma (ESCC). From: Genome-wide association studies of gastric adenocarcinoma and esophageal squamous cell carcinoma identify a shared susceptibility locus in PLCE1 at 10q23.

P-values were derived from 1 df trend tests in logistic regression models adjusted for age, sex, and study and are shown with the LR values for putative recombination hotspots using SequenceLDhot (vertical bars). Pair-wise r2are displayed at the bottom for all SNPs included in the GWAS analysis. Coordinates refer to genome Build 36.1. The figure depicts a region of chromosome 10q23 (95,980,823-96,174,210) that includes the PLCE1 gene and the different symbols indicate the four different endpoints of total GC, gastric cardia cancers, gastric noncardia cancers, or ESCC.

Christian C Abnet, et al. Nat Genet. ;44(10):1090-1097.

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