Figure 1

Figure 1. Schematic model of cellular reprogramming and the regulation pathways. From: Cellular reprogramming: a small molecule perspective.

Pluripotency reprogramming is a slow and stochastic process that is regulated by several interconnected mechanisms. Transient overexpression of reprogramming factors in fibroblasts leads to the rapid generation of epigenetically “activated” cells (unstable intermediate), which can be coaxed to various cell states by using lineage-specific conditions. iPSCs are one of the outcomes. Besides iPSCs, many lineage-specific cells and progenitor cells can be obtained. Only some representative small molecules and transcription factors are shown here.

Baoming Nie, et al. Curr Opin Cell Biol. 2012 December;24(6):784-792.

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