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Figure 1

Figure 1. From: Burden of Rare Sarcomere Gene Variants in the Framingham and Jackson Heart Study Cohorts.

Stratified Framingham Cardiovascular Phenotypes
(A) Longitudinal regression of LVWT scaled to height over time stratified by genetic risk only (defined by one or more sarcomere variants in the absence of physiological risk factors), presence of two or more physiological risk factors (hyperlipidemia, hypertension, obesity, or diabetes), or the combination of genetic and physiologic risk factors. The inset shows a bar graph of regression line slopes, with standard deviations.
(B) Longitudinal regression of left ventricular diastolic diameter (LVDD) scaled to height, stratified as above. A statistically significant decline (p < 0.05) is observed between the slope of individuals with and without genetic risk factors in the absence of physiologic risk factors.
(C) Kaplan-Meier curves showing age of first adverse cardiovascular event, stratified as described above. Increased risk for first adverse cardiovascular event conferred by genetic risk factor is significant (p < .01).

Alexander G. Bick, et al. Am J Hum Genet. 2012 September 7;91(3):513-519.

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