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1.
Figure 1

Figure 1. From: Oral administration of French maritime pine bark extract (Flavangenol®) improves clinical symptoms in photoaged facial skin.

Schematic outline of part 1 and part 2 of study using low-dose pine bark extract.
Abbreviation: PBE, pine bark extract.

Minao Furumura, et al. Clin Interv Aging. 2012;7:275-286.
2.
Figure 2

Figure 2. From: Oral administration of French maritime pine bark extract (Flavangenol®) improves clinical symptoms in photoaged facial skin.

Before (left) and 6 months after (right) treatment of photodamaged skin with oral pine bark extract.

Minao Furumura, et al. Clin Interv Aging. 2012;7:275-286.
3.
Figure 3

Figure 3. From: Oral administration of French maritime pine bark extract (Flavangenol®) improves clinical symptoms in photoaged facial skin.

The melanin index was significantly decreased after 4 and 12 weeks of oral administration of pine bark extract 100 mg/day.
Notes: The melanin index was calculated according to the method reported by Yamamoto et al. Values are expressed as the mean ± standard deviation. *P < 0.05 (Tukey–Kramer method), n = 24.

Minao Furumura, et al. Clin Interv Aging. 2012;7:275-286.
4.
Figure 5

Figure 5. From: Oral administration of French maritime pine bark extract (Flavangenol®) improves clinical symptoms in photoaged facial skin.

Facultative skin color was assessed using a colorimeter followed by individual typology angle value calculation.
Notes: The Mann–Whitney U test was used to determine differences between baseline and after treatment with pine bark extract. There are no significant differences between baseline and following treatment with pine bark extract (P > 0.05), n = 21.
Abbreviation: ITA, individual typology angle.

Minao Furumura, et al. Clin Interv Aging. 2012;7:275-286.
5.
Figure 6

Figure 6. From: Oral administration of French maritime pine bark extract (Flavangenol®) improves clinical symptoms in photoaged facial skin.

Time course of corneocyte size changes measured by a planimetric method during pine bark extract administration.
Notes: The mean surface size of the corneocytes decreased significantly after 5 months of treatment with pine bark extract. Values are expressed as the mean ± standard deviation of corneocyte surface area. *P < 0.05 (unpaired t-test); **P < 0.05 (Mann–Whitney U test), n = 21.

Minao Furumura, et al. Clin Interv Aging. 2012;7:275-286.
6.
Figure 4

Figure 4. From: Oral administration of French maritime pine bark extract (Flavangenol®) improves clinical symptoms in photoaged facial skin.

Time course of mean melanin index changes in age spots in group 1 (A) and group 2 (B).
Notes: A significant decrease in melanin index was seen after 4–8 weeks of oral pine bark extract 40 mg/day. Melanin index scores were calculated according to the method reported by Yamamoto et al. Values are expressed as the mean ± standard deviation. *P < 0.05 (Tukey–Kramer method), n = 38 (group 1), n = 39 (group 2).

Minao Furumura, et al. Clin Interv Aging. 2012;7:275-286.

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