Results: 2

1.
Fig. 2.

Fig. 2. From: Vitamin D accelerates resolution of inflammatory responses during tuberculosis treatment.

Immunomodulatory actions of vitamin D are not restricted to individuals with the tt genotype of the TaqI vitamin D receptor polymorphism. Vitamin D supplementation accelerates sputum culture conversion in patients with the tt genotype of the TaqI vitamin D receptor polymorphism (A), but not in those with the Tt (B) or TT (C) genotypes (Pinteraction = 0.03). Vitamin D, solid line; placebo, dotted line. In contrast, the immunomodulatory actions of vitamin D are not restricted to those with the tt genotype of the TaqI polymorphism. In patients with the TT genotype, vitamin D supplementation significantly reduced 8-wk circulating concentrations of CRP (D), CXCL9 (E), CXCL10 (F), NGAL (G), and LL-37 (H); in patients with the Tt genotype, statistically significant reductions in 8-wk serum concentrations of CXCL9 (E) and IL-10 (I) were also seen in patients randomized to vitamin D (Vit D) vs. Placebo (Plac). Data for patients with the tt genotype are not presented because of small numbers entering per-protocol analysis. Line at median; TT placebo (□) n = 23, TT vitamin D (■) n = 22, Tt placebo (○) n = 21, Tt vitamin D (●) n = 19. LOD, limit of detection.

Anna K. Coussens, et al. Proc Natl Acad Sci U S A. 2012 September 18;109(38):15449-15454.
2.
Fig. 1.

Fig. 1. From: Vitamin D accelerates resolution of inflammatory responses during tuberculosis treatment.

Kinetics of circulating and antigen-stimulated immune responses during the course of antituberculous therapy in the presence vs. the absence of adjunctive vitamin D. Vitamin D accelerated sputum smear conversion in patients fulfilling per-protocol analysis criteria (A). Monocyte counts fell more quickly (B) and lymphocyte counts rose more quickly (C) among patients in the intervention arm of the trial. Vitamin D also accelerated treatment-induced decreases in ESR (D), circulating concentrations of CXCL9 (E), CXCL10 (F), MMP-9 (G), and LL-37 (H) and rCFP-10–stimulated supernatant concentrations of IL-1RA (I), IL-6 (J), IL-12p40/p70 (K), and TNF (L). Means ± SEM at 0, 2, 4, 6, and 8 wk of treatment are presented. Dotted lines, placebo arm; solid lines, vitamin D arm.

Anna K. Coussens, et al. Proc Natl Acad Sci U S A. 2012 September 18;109(38):15449-15454.

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