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Results: 5

1.
Figure 2

Figure 2. A TRPA1 antagonist, HC-030031, alleviates mechanical hyperalgesia.. From: TRPA1 Mediates Mechanical Sensitization in Nociceptors during Inflammation.

Treatment groups were divided into CFA+vehicle, saline+vehicle, CFA+HC-030031 and saline+HC-030031 (100 µg HC-030031 in vehicle). A, Mechanical paw withdrawal threshold for each group in the injected paw (white) and uninjected paw (grey). B, Thermal paw withdrawal latency for each group in the injected paw (white) and uninjected paw (grey). *, two-way ANOVA followed by a Bonferroni post-hoc test of all four groups.

Richard C. Lennertz, et al. PLoS One. 2012;7(8):e43597.
2.
Figure 4

Figure 4. TRPA1-expressing fibers drive behavioral mechanical hyperalgesia.. From: TRPA1 Mediates Mechanical Sensitization in Nociceptors during Inflammation.

Treatment groups were divided into CFA-QX-314, saline-QX-314, CFA-QX-314+cinnamaldehyde (cinn) and saline-QX-314+cinn (concentrations were 0.2% QX and 30 µM cinn). A, Mechanical paw withdrawal threshold for each group in the injected paw (white) and uninjected paw (grey). B, Thermal paw withdrawal latency for each group in the injected paw (white) and uninjected paw (grey). *, two-way ANOVA followed by a Bonferroni post-hoc test of all four groups.

Richard C. Lennertz, et al. PLoS One. 2012;7(8):e43597.
3.
Figure 5

Figure 5. Inflammation increases mechanical responses of CMC fibers.. From: TRPA1 Mediates Mechanical Sensitization in Nociceptors during Inflammation.

Force-responses curves for A, CMC fibers B, CM fibers C, CMHC fibers and D, CMH fibers from CFA-injected and saline-injected mice. E, Action potentials fired by CMC fibers during a 20 mN (top) and 150 mN (bottom) mechanical stimulus, displayed in 0.5 sec bins. F, Scatterplot of individual C fiber responses to a 150 mN mechanical stimulus. G, Scatterplot of C fiber mechanical threshold, as determined by calibrated von Frey filament. H, Distribution of C fiber subtypes characterized from CFA-injected and saline-injected mice. *, two-way ANOVA followed by a Bonferroni post-hoc test.

Richard C. Lennertz, et al. PLoS One. 2012;7(8):e43597.
4.
Figure 3

Figure 3. A TRPA1 antagonist, HC-030031, completely normalizes C fiber responses to mechanical stimuli.. From: TRPA1 Mediates Mechanical Sensitization in Nociceptors during Inflammation.

A, Force-response curves for C fibers from CFA-injected mice in the presence of either HC-030031 (30 µM) or vehicle. B, Example C fiber response from a CFA-injected mouse (top) and a CFA-injected mouse in the presence of HC-030031 (bottom) to 5, 20 and 100 mN mechanical stimuli. A smaller, spontaneously-active fiber is noticeable in the bottom trace. C, Action potentials fired during a 20 mN (top) and 150 mN (bottom) mechanical stimulus in the presence in CFA-injected mice, displayed in 0.5 sec bins. D, Scatterplot of individual C fiber responses to a 20 mN (left) and 150 mN (right) mechanical stimulus in CFA-injected mice. *, two-way ANOVA followed by a Bonferroni post-hoc test.

Richard C. Lennertz, et al. PLoS One. 2012;7(8):e43597.
5.
Figure 1

Figure 1. CFA-induced inflammation increases suprathreshold mechanical responses in C fibers.. From: TRPA1 Mediates Mechanical Sensitization in Nociceptors during Inflammation.

A, Comparisons of average paw height (left), paw withdrawal threshold for mechanical stimuli (center) and paw withdrawal latency from a noxious heat stimulus (right) in both the injected and uninjected hind paws of saline-injected and CFA-injected mice. B, Force-response curve for C fibers from CFA-injected and saline-injected mice. C, Example C fiber response from a saline-injected mouse (top) and CFA-injected mouse (bottom) to 5, 20 and 100 mN mechanical stimuli. A second fiber with a low-amplitude waveform is noticeable in the bottom trace. D, Action potentials fired during a 20 mN (top) and 150 mN (bottom) mechanical stimulus, displayed in 0.5 sec bins. E, Scatterplot of individual C fiber responses to a 20 mN (left) and 150 mN (right) mechanical stimulus. F, Force-response curve for AM fibers from CFA-injected and saline-injected mice. G, Example AM fiber response from a saline-injected mouse (top) and CFA-injected mouse (bottom) to 5, 20 and 100 mN mechanical stimuli. *, two-way ANOVA followed by a Bonferroni post-hoc test.

Richard C. Lennertz, et al. PLoS One. 2012;7(8):e43597.

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