Results: 2

1.
Figure 1

Figure 1. From: A low frequency variant at 8q24.21 is strongly associated with risk of oligodendroglial tumors and IDH1 or IDH2 mutated astrocytomas.

Case-control SNP associations with oligodendroglioma risk for 157 SNPs within the 8q24.21 (CCDC26) region by study site, Mayo Clinic (red) and University of California San Francisco (UCSF) (blue). The −log10 p-value of the association of each SNP versus chromosome 8q24 position is plotted. Only Stage 2 validation genotyping data are illustrated. The recombination rate for the region using HapMap is plotted in the lower part of the figure.

Robert B. Jenkins, et al. Nat Genet. 2012 October;44(10):1122-1125.
2.
Figure 2

Figure 2. From: A low frequency variant at 8q24.21 is strongly associated with risk of oligodendroglial tumors and IDH1 or IDH2 mutated astrocytomas.

Glioma case-control odds ratios (ORs), 95% confidence intervals (CIs), and (−log10p) for SNPs within the 8q24.21 (CCDC26) region. A: Associations of all gliomas with 7 most strongly and significantly associated SNPs along with two SNPs from prior studies (1, 2) (rs4295627 and rs891835). B: Associations of rs55705857 G allele with various glioma morphologic subtypes. C: Association of rs55705857 G allele with glioma morphologic subtypes further stratified by presence or absence of tumor IDH1 or IDH2 mutation. Only Stage 2 validation genotyping data are illustrated. Abbreviations: MOA=mixed oligoastrocytoma, Oligo=oligodendroglioma, GBM=glioblastoma

Robert B. Jenkins, et al. Nat Genet. 2012 October;44(10):1122-1125.

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