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1.
Figure 3

Figure 3. Best objective functions for FBA, regarding substrate type, knowing the oxygen uptake rate.. From: Predictive Potential of Flux Balance Analysis of Saccharomyces cerevisiae Using as Optimization Function Combinations of Cell Compartmental Objectives.

Errors of the FBA estimations using the five best compartmentalized objective functions Z (for every case), and “max biomass production” and “max ATP production” functions. The compartmental objectives that correspond to minimizations have negative sign, so Z is always maximized. Biomass error: error percentage in the estimation of the specific growth rate (blue boxes). Exchange fluxes error: Euclidean distance between the estimated values and the experimental values of the known exchange fluxes (green boxes). A: Experiments with glucose as substrate. B: Experiments with substrates other than glucose. prod.: production; cons.: consumption; cyt: cytosolic; mit: mitochondrial; trans t cyt: transport towards cytosol.

Carlos Eduardo García Sánchez, et al. PLoS One. 2012;7(8):e43006.
2.
Figure 2

Figure 2. Best objective functions for FBA, regarding specific growth rate, knowing the oxygen uptake rate.. From: Predictive Potential of Flux Balance Analysis of Saccharomyces cerevisiae Using as Optimization Function Combinations of Cell Compartmental Objectives.

Errors of the FBA estimations using the five best compartmentalized objective functions Z (for every clasification), and “max biomass production” and “max ATP production” functions. The compartmental objectives that correspond to minimizations have negative sign, so Z is always maximized. Biomass error: error percentage in the estimation of the specific growth rate (blue boxes). Exchange fluxes error: Euclidean distance between the estimated values and the experimental values of the known exchange fluxes (green boxes). A: Growth rate less than or equal to 0.15 h−1. B: Growth rate higher than 0.15 h−1 and lower than or equal to 0.28 h−1. C: Growth rate higher than 0.28 h−1. prod.: production; cons.: consumption; cyt: cytosolic; mit: mitochondrial; trans t cyt: transport towards cytosol.

Carlos Eduardo García Sánchez, et al. PLoS One. 2012;7(8):e43006.
3.
Figure 1

Figure 1. Best objective functions for FBA, regarding presence of oxygen in the medium.. From: Predictive Potential of Flux Balance Analysis of Saccharomyces cerevisiae Using as Optimization Function Combinations of Cell Compartmental Objectives.

Errors of the FBA estimations using the five best compartmentalized objective functions Z (for every category), and “max biomass production” and “max ATP production” functions. The compartmental objectives that correspond to minimizations have negative sign, so Z is always maximized. Biomass error: error percentage in the estimation of the specific growth rate (blue boxes). Exchange fluxes error: Euclidean distance between the estimated values and the experimental values of the known exchange fluxes (green boxes). A: Anaerobic growth. B: Aerobic growth with known flux exchange of oxygen. C: Aerobic growth with unknown oxygen uptake. D: Aerobic growth with unknown oxygen uptake, in batch experiments (exponential phase). prod.: production; cons.: consumption; cyt: cytosolic; mit: mitochondrial; trans t cyt: transport towards cytosol.

Carlos Eduardo García Sánchez, et al. PLoS One. 2012;7(8):e43006.

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