Results: 4

1.
Figure 3

Figure 3. From: Early cardiac development: a view from stem cells to embryos.

Cardiac fields and lineages. The cartoon depicts the cardiogenic tree with specific fields and lineages as described in the last decade literature.

Patrick Van Vliet, et al. Cardiovasc Res. 2012 December 1;96(3):352-362.
2.
Figure 4

Figure 4. From: Early cardiac development: a view from stem cells to embryos.

Genetic and epigenetic regulation of the cardiogenic transcriptional network. Both the NURF and the SWI/SNF complexes participate in the modulation of expression of genes required for cardiogenesis. The figure briefly summarizes the key stages through which the embryo develops to generate its heart and the major genes participating within networks in cardiogenesis. The enzymes written in red have specifically been reported to regulate expression of genes important for normal cardiogenesis.

Patrick Van Vliet, et al. Cardiovasc Res. 2012 December 1;96(3):352-362.
3.
Figure 2

Figure 2. From: Early cardiac development: a view from stem cells to embryos.

Early segregation of the cardiogenic and haemogenic roads. A likely existing bipotent early progenitor in the epiblast gives rise to both a Flk1+ /Brachyury+ and a Flk1-/Brachyury+ cell population, under the action of BMP4 secreted by the extraembryonic ectoderm (ExE) and BMP2 in the visceral endoderm (VE), respectively. This early event already segregates the future haemogenic and cardiogenic (i.e. myocardial) cell populations. A parallel route used by a Flk1+ lineage re-emerging from a Flk1- cell population, and also possibly part from the hemangioblast lineage leads to the endocardial cell population.

Patrick Van Vliet, et al. Cardiovasc Res. 2012 December 1;96(3):352-362.
4.
Figure 1

Figure 1. From: Early cardiac development: a view from stem cells to embryos.

Comparison of cardiac ES cell differentiation and early embryonic heart development. (A) Time course and embryonic stages of cardiogenesis in mouse embryo. (B) Time course and embryonic stages recapitulated by ESC to differentiate towards a cardiac fate. (C) Time course and pattern of expression of MesP1 in early mouse embryo monitored by in situ hybridization (left panel). MesP1 Cell lineage tracing in embryos obtained from breeding MesP1-Cre with Rosa26lacZ (R26R) mice (right panel). MesP1+ cells give rise to the whole heart, as well as head and tail muscles. ExE, extraembryonic ectoderm; VE, visceral endoderm; DE, definitive endoderm.

Patrick Van Vliet, et al. Cardiovasc Res. 2012 December 1;96(3):352-362.

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