Results: 3

1.
Figure 1

Figure 1. From: Effects of Growth Hormone-Releasing Hormone on Cognitive Function in Adults With Mild Cognitive Impairment and Healthy Older Adults.

Consolidated Standards of Reporting Trials flow diagram of healthy older adults and adults with mild cognitive impairment (MCI). AE indicates adverse event; GHRH, growth hormone–releasing hormone; and IGF-1, insulinlike growth factor 1.

Laura D. Baker, et al. Arch Neurol. 2012 November;69(11):1420-1429.
2.
Figure 3

Figure 3. From: Effects of Growth Hormone-Releasing Hormone on Cognitive Function in Adults With Mild Cognitive Impairment and Healthy Older Adults.

Mean serum insulinlike growth factor 1 (IGF-1) levels at baseline (week 0) and at weeks 10 and 20 (to convert to nanomoles per liter, multiply by 0.131). The IGF-1 levels increased with the administration of growth hormone–releasing hormone (GHRH) (P < .001), with no differences observed as a function of time (week 10 vs week 20) or diagnosis (healthy vs mild cognitive impairment [MCI]). Error bars indicate standard error of the mean.

Laura D. Baker, et al. Arch Neurol. 2012 November;69(11):1420-1429.
3.
Figure 2

Figure 2. From: Effects of Growth Hormone-Releasing Hormone on Cognitive Function in Adults With Mild Cognitive Impairment and Healthy Older Adults.

Cognitive response to growth hormone–releasing hormone (GHRH). Mean z scores representing change from baseline in composites of executive function (A) and verbal memory (B), expressed as residualized change scores. Treatment with GHRH had favorable effects on executive function (P = .005) as measured by Task Switching accuracy, Stroop Color-Word Interference reaction time (voice onset latency) on “interference” trials, Self-Ordered Pointing Test accuracy, and Word Fluency. A similar trend was observed for verbal memory (P = .08) as measured by total recall (immediate + delayed) on the Hopkins Verbal Learning Test and total Story Recall. Pairwise comparisons between subgroups defined by diagnosis are not presented because the main finding indicates a treatment effect for the groups combined and no treatment × diagnosis interaction. Visual memory did not benefit from GHRH administration. Error bars indicate standard error of the mean. MCI indicates mild cognitive impairment.

Laura D. Baker, et al. Arch Neurol. 2012 November;69(11):1420-1429.

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