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Results: 4

1.
Figure 3

Figure 3. From: Abnormal behavior in mice mutant for the Disc1 binding partner, Dixdc1.

Motivation- and anxiety-like behavior in Dixdc1−/− mice. (a) Time immobile in the forced swim test (Student's t-test). (b) Time in the open arms of the elevated plus-maze (Student's t-test). WT, wild type; p,probability value.

S Kivimäe, et al. Transl Psychiatry. 2011 September;1(9):e43.
2.
Figure 2

Figure 2. From: Abnormal behavior in mice mutant for the Disc1 binding partner, Dixdc1.

Spontaneous locomotion of Dixdc1 −/− mice. (a) Locomotor activity in an open field (Repeated measures two-way analysis of variance (ANOVA), wild type (WT) vs −/−, F(1, 187)=5.88). (b) Vertical counts in an open field (Repeated measures two-way ANOVA, WT vs −/−, F(1, 187)=13.76). (c) Number of ambulatory bouts (Student's t-test). (d) Average speed during ambulatory bouts (Student's t-test, P=0.28). NS, not significant; P, probability value.

S Kivimäe, et al. Transl Psychiatry. 2011 September;1(9):e43.
3.
Figure 4

Figure 4. From: Abnormal behavior in mice mutant for the Disc1 binding partner, Dixdc1.

Baseline acoustic startle and prepulse inhibition (PPI) in Dixdc1−/− mice. (a) Acoustic startle response (Repeated measures two-way analysis of variance (ANOVA), Interaction, F(7, 119)=3.60 followed by the Bonferroni multiple comparison test, P<0.01 for 110 dB) (b) PPI of the acoustic startle response (Repeated measures two-way ANOVA, wild type (WT) vs mutant, F(1, 68)=0.47, P=0.47). NS, not significant.

S Kivimäe, et al. Transl Psychiatry. 2011 September;1(9):e43.
4.
Figure 1

Figure 1. From: Abnormal behavior in mice mutant for the Disc1 binding partner, Dixdc1.

Generation of Dixdc1-mutant mice. (a) Schematic representation of Dixdc1 gene-targeting strategy. Exons B2, 2 and 3 were replaced by a neo cassette by homologous recombination, which is predicted to introduce a premature stop codon in all Dixdc1 transcripts. (b) Northern blot of postnatal cerebral cortical lysates using a probe complementary to most of the Dixdc1 coding sequence (Methods). GAPDH, glyceraldehyde-3-phosphate dehydrogenase; WT, wild type.

S Kivimäe, et al. Transl Psychiatry. 2011 September;1(9):e43.

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