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1.
Figure 1

Figure 1. From: Near-infrared spectral tomography integrated with digital breast tomosynthesis: Effects of tissue scattering on optical data acquisition design.

Software procedures used in simulation. Lower left shows source and detector configurations for the FD (left) and CW (right) data for a given patient.

Kelly Michaelsen, et al. Med Phys. 2012 July;39(7):4579-4587.
2.
Figure 2

Figure 2. From: Near-infrared spectral tomography integrated with digital breast tomosynthesis: Effects of tissue scattering on optical data acquisition design.

Region-guided reconstruction of NIRST data involved segmentation of (a) DBT slice (arrow highlights the region of interest), creating (b) a bitmap from which (c) a volume mesh was generated. The data were simulated and reconstructed on the mesh creating (d) a coregistered image of the optical properties of the breast.

Kelly Michaelsen, et al. Med Phys. 2012 July;39(7):4579-4587.
3.
Figure 6

Figure 6. From: Near-infrared spectral tomography integrated with digital breast tomosynthesis: Effects of tissue scattering on optical data acquisition design.

Solid line shows the mean and standard deviation of the average HbT recovered in the image volume from all patient cases as a function of error in optical scattering. Data points show the same analysis from the phantom experiments.

Kelly Michaelsen, et al. Med Phys. 2012 July;39(7):4579-4587.
4.
Figure 4

Figure 4. From: Near-infrared spectral tomography integrated with digital breast tomosynthesis: Effects of tissue scattering on optical data acquisition design.

Illustrative example of a patient simulation with a benign lesion: (a) scattering amplitude, (b) oxyhemoglobin (μm), (c) water fraction (percent), (d) scattering power, (e) deoxyhemoglobin (μm), and (f) lipids content (percent). Exact (simulated) distribution is shown on the left while the corresponding recovered image is shown on the right for each quantity.

Kelly Michaelsen, et al. Med Phys. 2012 July;39(7):4579-4587.
5.
Figure 5

Figure 5. From: Near-infrared spectral tomography integrated with digital breast tomosynthesis: Effects of tissue scattering on optical data acquisition design.

Relative error in the adipose and fibroglandular region for 3 and 6 wavelength reconstructions for all eight subject simulations in (a) scattering amplitude and (b) scattering power. (c) Error in HbT relative to the actual concentration for 3 and 6 wavelengths in adipose, fibroglandular, and tumor regions. (d) Error in HbT relative to actual concentration for single bulk and two-region scatter estimations in adipose, fibroglandular, and tumor regions.

Kelly Michaelsen, et al. Med Phys. 2012 July;39(7):4579-4587.
6.
Figure 3

Figure 3. From: Near-infrared spectral tomography integrated with digital breast tomosynthesis: Effects of tissue scattering on optical data acquisition design.

Illustrative example of a patient simulation with a malignant lesion: (a) scattering amplitude, (b) oxyhemoglobin (μm), (c) water fraction (percent), (d) scattering power, (e) deoxyhemoglobin (μm), and (f) lipid content (percent). Exact (simulated) distribution is shown on the left while the corresponding recovered image is shown on the right for each quantity.

Kelly Michaelsen, et al. Med Phys. 2012 July;39(7):4579-4587.
7.
Figure 7

Figure 7. From: Near-infrared spectral tomography integrated with digital breast tomosynthesis: Effects of tissue scattering on optical data acquisition design.

(a) Detector panel used for phantom measurements. (b) Agar phantom with a liquid inclusion used for instrumentation and simulation validation. (c) DBT slice of the agar phantom. (d) Actual (top) and reconstructed (bottom) phantom image for oxygenated hemoglobin concentration. (e) Recovered hemoglobin concentration compared to the actual value in the inclusion and background. Inclusion hemoglobin values are the three higher data points with actual values depicted in the positively sloping line. Background hemoglobin levels were kept constant and are the three lower data points with actual values depicted in the horizontal line.

Kelly Michaelsen, et al. Med Phys. 2012 July;39(7):4579-4587.

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