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Results: 5

1.
Figure 2

Figure 2. Tissue- and age-dependent expression of HIV-1 Tat in the brain, liver, and spleen of the HIV-1Tg rat. From: Age and ethanol concentration-dependent effects of acute binge drinking in the HIV-1 transgenic rat.

The hypothalamus, hippocampus, liver, and spleen of adult (PD 84) and adolescent (PD 30–37) HIV-1Tg rats were harvested and analyzed for HIV-1 Tat expression using a qRT-PCR. Values represent the mean ± SEM (n = 4 rats per tissue type for each age group).

Sraboni Sarkar, et al. Alcohol Clin Exp Res. 2013 January;37(Suppl 1):E70-E78.
2.
Figure 5

Figure 5. Age-dependent effect of alcohol (20% EtOH) on the locomotor activity of adult and adolescent HIV-1Tg rats. From: Age and ethanol concentration-dependent effects of acute binge drinking in the HIV-1 transgenic rat.

Locomotor activity (distance travelled in cm in 25 min) was assessed in adult (PD 84) and adolescent (PD 30–37) HIV-1Tg and F344 rats treated with 20% EtOH solution using a 3-d binge regimen (total dose of 4.8 g/kg/day). Values represent the mean ± SEM (n = 6–10 rats per treatment for each age group). *p< 0.05; **p < 0.01; ***p<0.001.

Sraboni Sarkar, et al. Alcohol Clin Exp Res. 2013 January;37(Suppl 1):E70-E78.
3.
Figure 4

Figure 4. Age- and EtOH concentration-dependent expression of IL-1β and IL-10 in adult and adolescent HIV-1Tg rats. From: Age and ethanol concentration-dependent effects of acute binge drinking in the HIV-1 transgenic rat.

IL-1β and IL-10 expression was measured (fold change) in the brain, liver, and spleen of adult (PD 84) and adolescent (PD 30–37) HIV-1Tg rats treated with 0% (water control), 20% EtOH, and 52% EtOH in a 3-d binge regimen (total dose of 4.8 g/kg/day). Data were calculated using the ΔΔCT method relative to water control (0% EtOH) and represented as fold change (n = 4 rats for each age group per tissue type for each EtOH concentration). *p< 0.05; **p < 0.01; ***p<0.001.

Sraboni Sarkar, et al. Alcohol Clin Exp Res. 2013 January;37(Suppl 1):E70-E78.
4.
Figure 3

Figure 3. Age- and EtOH concentration-dependent HIV-1 Tat expression in adult and adolescent HIV-1Tg rats. From: Age and ethanol concentration-dependent effects of acute binge drinking in the HIV-1 transgenic rat.

HIV-1 Tat expression (copies/μg of total RNA) was measured in the brain, liver, and spleen of adult (PD 84) and adolescent (PD 30–37) HIV-1Tg rats administered (i.g.) 0% (water control), 20% EtOH, or 52% EtOH solution in a 3-d binge regimen (total dose of 4.8 g/kg/day). Values represent the mean ± SEM (n = 4 for each age group per tissue type for each EtOH concentration). *p< 0.05; **p < 0.01; ***p<0.001.

Sraboni Sarkar, et al. Alcohol Clin Exp Res. 2013 January;37(Suppl 1):E70-E78.
5.
Figure 1

Figure 1. Time course of blood EtOH concentration following binge treatment with 20% EtOH versus 52% EtOH. From: Age and ethanol concentration-dependent effects of acute binge drinking in the HIV-1 transgenic rat.

F344 rats were given i.g. treatment of a 0% (water control), 20% EtOH, or 52% EtOH solution (total dose = 2.4 g/kg), and the blood EtOH concentration in serum was determined at 0, 15, 45, and 90 min post treatment. Values represent the mean ± SEM (n = 4 rats for each group per time point). *p< 0.05.

Sraboni Sarkar, et al. Alcohol Clin Exp Res. 2013 January;37(Suppl 1):E70-E78.

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