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1.
Fig 2

Fig 2. From: Prospective, high-throughput molecular profiling of human gliomas.

Detection of gene amplification by fluorescence in situ hybridization (FISH). Tumor cells show EGFR amplification in a (orange signals) and MET amplification in b (pink signals). The CEP7 chromosome (centromere control) is represented by aqua signals (white arrowheads). Nuclei are stained with 4′,6-diamidino-2-phenylindole

Andrew S. Chi, et al. J Neurooncol. ;110(1):89-98.
2.
Fig 1

Fig 1. From: Prospective, high-throughput molecular profiling of human gliomas.

Representative examples of SNaPshot tumor genotyping. The top panels show genotyping data obtained for normal male genomic DNA (Promega, Madison, WI) and the bottom panels show data derived from patient GBM tumors. Mutant and wild-type alleles are distinguished based on the slightly different positions and on the distinct colors of their corresponding peaks. Arrows indicate mutant alleles. a Identification of the IDH1 R132H (cDNA nucleotide change 395C>A) mutation in one GBM specimen. Assays: (1) IDH1 R132; (2) EGFR E746_A750; (3) EGFR L858; (4) CTNNB1 S45; (5) PIK3CA E542; (6) NRAS G12; (7) EGFR L861 and (8) AKT1 E17. b Identification of the PIK3CA H1047R (3140A>G) mutation in another GBM tumor. Assays: (1) PIK3CA H1047; (2) CTNNB1 G34; (3) BRAF V600; (4) NRAS G13; (5) PIK3CA Q546; (6) APC R1450 and (7) APC R1114

Andrew S. Chi, et al. J Neurooncol. ;110(1):89-98.

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