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Results: 3

1.
Figure 1

Figure 1. From: High-Density Lipoprotein Cholesterol and Particle Concentrations, Carotid Atherosclerosis and Coronary Events: The Multi-Ethnic Study of Atherosclerosis.

Scatterplot of HDL-C with HDL-P
All results except Fig 1 are adjusted for base covariates (base cov.): age, sex, ethnicity, hypertension, and smoking. Error bars are standard errors; p values are for linear trend.

Rachel H. Mackey, et al. J Am Coll Cardiol. 2012 August 7;60(6):508-516.
2.
Figure 2

Figure 2. From: High-Density Lipoprotein Cholesterol and Particle Concentrations, Carotid Atherosclerosis and Coronary Events: The Multi-Ethnic Study of Atherosclerosis.

Mean cIMT (μm) across quartiles of HDL-C or HDL-P, before and after adjusting for LDL-P and each other (n=5541).
A. Mean cIMT (μm) across HDL-C quartiles, adjusted for base covariates, p <0.001; adjusted for base covariates plus LDL-P, p=0.01; adjusted for base covariates plus HDL-P, p=0.051, and adjusted for base covariates plus LDL-P and HDL-P, p=0.75.
B. Mean cIMT (μm) across HDL-P quartiles; adjusted for base covariates, p <0.0001; adjusted for base covariates plus LDL-P, p=0.0001; adjusted for base covariates plus HDL-C, p=0.002; adjusted for base covariates plus LDL-P and HDL-C, p<0.001
All results except Fig 1 are adjusted for base covariates (base cov.): age, sex, ethnicity, hypertension, and smoking. Error bars are standard errors; p values are for linear trend.

Rachel H. Mackey, et al. J Am Coll Cardiol. 2012 August 7;60(6):508-516.
3.

Figure 3. From: High-Density Lipoprotein Cholesterol and Particle Concentrations, Carotid Atherosclerosis and Coronary Events: The Multi-Ethnic Study of Atherosclerosis.

Mean cIMT (μm) by joint tertiles of HDL-C and HDL-P, entire group, and stratified by median LDL-P (1236.5 nmol/l). All models adjusted for base covariates.
HDL-C tertiles (mg/dl): low HDL-C (≤42), medium HDL-C (43-54), high HDL-C: (≥55.) HDL-P tertiles (μmol/l): low HDL-P (≤30.5), medium HDL-P (30.6-36.1), high HDL-P: (≥30.6).
A. Entire study sample.
P for HDL-C trend within each HDL-P tertile= not significant.
P for HDL-P trend <0.05 for both low and high HDL-C tertiles, not significant for medium HDL-C tertiles. B. Participants with LDL-P below the median.
P for HDL-C trend within each HDL-P tertile: not significant.
P for HDL-P trend within HDL-C tertile= 0.06, 0.09, 0.02 for low, medium and high HDL-C tertiles, respectively.
C. Participants with LDL-P above the median.
Neither HDL-C trends within each HDL-P tertile, nor HDL-P trends within each HDL-C tertile were significant.
All results except Fig 1 are adjusted for base covariates (base cov.): age, sex, ethnicity, hypertension, and smoking. Error bars are standard errors; p values are for linear trend.

Rachel H. Mackey, et al. J Am Coll Cardiol. 2012 August 7;60(6):508-516.

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