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Results: 4

1.
Figure 4

Figure 4. From: Effects of genetic deletion of the Kv4.2 voltage-gated potassium channel on murine anxiety-, fear- and stress-related behaviors.

Exaggerated swim-induced corticosterone and normal responses to swim stressors in Kv4.2 knockout (KO) mice. (A) Genotypes did not differ in percentage immobility during a single 6-minute forced-swim exposure (n = 9-13/genotype). (B) KO mice had significantly raised serum corticosterone levels after the single forced-swim exposure (n = 9-13/genotype). (C) Genotypes had a similar increase in percentage immobility increased over 10 × 1-min inescapable forced swim exposures (n = 14-18/genotype). Data are mean ± SEM. **P < 0.01.

Carly Kiselycznyk, et al. Biol Mood Anxiety Disord. 2012;2:5-5.
2.
Figure 1

Figure 1. From: Effects of genetic deletion of the Kv4.2 voltage-gated potassium channel on murine anxiety-, fear- and stress-related behaviors.

Increased exploratory rearing in Kv4.2 knockout (KO) mice. (A) KO mice showed more rearing behavior than wild-type (WT) controls in a novel empty-cage environment. (B) Genotypes did not differ in nociception as measured by the hot-plate tes, or in (C) the acoustic startle response (D) or prepulse inhibition of startle. (E) Light and dark phase home-cage activity was similar between genotypes. Data are mean ± SEM; n = 8-10/genotype. *P < 0.05; **P < 0.01.

Carly Kiselycznyk, et al. Biol Mood Anxiety Disord. 2012;2:5-5.
3.
Figure 3

Figure 3. From: Effects of genetic deletion of the Kv4.2 voltage-gated potassium channel on murine anxiety-, fear- and stress-related behaviors.

Increased freezing to unconditioned tones in Kv4.2 knockout (KO) mice. (A) During conditioning KO mice froze more than wild-type (WT) controls during the first (before conditioning) and second conditioned stimulus (CS) presentation trials. (B) Genotypes showed equivalent initial freezing and similar reductions in freezing from the first to the last five CS trial block during extinction training. Genotypes did not differ in freezing during (C) extinction retrieval or (D) fear renewal. Data are mean ± SEM; n = 8-12/genotype. *P < 0.05; **P < 0.01.

Carly Kiselycznyk, et al. Biol Mood Anxiety Disord. 2012;2:5-5.
4.
Figure 2

Figure 2. From: Effects of genetic deletion of the Kv4.2 voltage-gated potassium channel on murine anxiety-, fear- and stress-related behaviors.

Increased open-field locomotor activity and test-specific decreases in anxiety-like behavior in Kv4.2 knockout (KO) mice. KO mice traveled farther than wild-type (WT) controls in a novel open-field test, as shown via (A) a time-course analysis) and (B) over the full session. (C) Time spent in the center of the open field did not differ between genotypes. In the light/dark exploration test, genotypes did not differ in (D) percentage time spent in the lighted compartment, (E) entries into the lighted compartment or (F) distance traveled throughout the apparatus. In the elevated plus maze, KO mice spent a greater percentage of the session (G) in the open arms and made more entries into (H) the open arms, but not into (I) the closed arms, compared with wild-type (WT) controls. Data are mean ± SEM; n = 8-12/genotype. *P < 0.05; **P < 0.01.

Carly Kiselycznyk, et al. Biol Mood Anxiety Disord. 2012;2:5-5.

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