Results: 5

1.
Fig. 3

Fig. 3. From: A Cleavable Scaffold Strategy for the Synthesis of One-Bead One-Compound Cyclic Peptoid Libraries That Can Be Sequenced By Tandem Mass Spectrometry.

Photomicrograph of beads from the cyclic peptoid library after subjecting them to the ninhydrin test.

Levi S. Simpson, et al. Tetrahedron Lett. ;53(18):2341-2344.
2.
Figure 1

Figure 1. From: A Cleavable Scaffold Strategy for the Synthesis of One-Bead One-Compound Cyclic Peptoid Libraries That Can Be Sequenced By Tandem Mass Spectrometry.

The dual methionine strategy for the creation of bead-displayed libraries of cyclic peptoids with a cleavable ring and linker.

Levi S. Simpson, et al. Tetrahedron Lett. ;53(18):2341-2344.
3.
Figure 4

Figure 4. From: A Cleavable Scaffold Strategy for the Synthesis of One-Bead One-Compound Cyclic Peptoid Libraries That Can Be Sequenced By Tandem Mass Spectrometry.

(a) General structure of cleaved compounds and the MALDI mass spectrum of cleaved Hit 1. (b) The 15 sequencable compounds identified in the screen.

Levi S. Simpson, et al. Tetrahedron Lett. ;53(18):2341-2344.
4.
Figure 5

Figure 5. From: A Cleavable Scaffold Strategy for the Synthesis of One-Bead One-Compound Cyclic Peptoid Libraries That Can Be Sequenced By Tandem Mass Spectrometry.

Characterization of the protein-binding properties of Hit 1 as measured by fluorescence polarization. A. (▲) Cyclic Hit 1, (●) Cyclic Hit 16, (■) Linear Hit 1 [NAc-Met-Nasp-Nasp-Namy-Npip-Npip-Npip-Nmea-Cys-Fluor]. B. (▲) Cyclic Hit 1 [Nasp-Nasp-Namy-Npip-Npip-Npip], (■) Scrambled [Npip-Namy-Nasp-Npip-Nasp-Npip]. C. (▲) Cyclic Hit 1 binding to streptavidin, (●) Non-hit cyclic compound [Npea-Namy-Nlys-Narg-Nlys-Npea] binding to streptavidin, (■) Cyclic Hit 1 binding to cholera toxin.

Levi S. Simpson, et al. Tetrahedron Lett. ;53(18):2341-2344.
5.
Fig. 2

Fig. 2. From: A Cleavable Scaffold Strategy for the Synthesis of One-Bead One-Compound Cyclic Peptoid Libraries That Can Be Sequenced By Tandem Mass Spectrometry.

General structure and synthetic route to the combinatorial library of macrocyclic peptoids. The ten amines shown at the bottom of the figure were employed in the split and pool synthesis. The Boc and OtBu protecting groups shown on the amines were removed on resin after completion of the library.

Levi S. Simpson, et al. Tetrahedron Lett. ;53(18):2341-2344.

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