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Results: 4

1.
Fig. 2

Fig. 2. Bacterial diversity increases with age in each population. From: Human gut microbiome viewed across age and geography.

Number of observed 97%ID OTUs plotted against age for (a) all subjects, (b) during the first 3 years of life, and (c) adults (in the latter panel, average values ± SEM are plotted). *p<0.05, **p<0.005 (ANOVA with Bonferroni post-hoc test).

Tanya Yatsunenko, et al. Nature. ;486(7402):222-227.
2.
Fig. 4

Fig. 4. Differences in the fecal microbiota between family members across the three populations studied. From: Human gut microbiome viewed across age and geography.

UniFrac distances between the fecal bacterial communities of family members were calculated (n=19 Amerindian, 34 Malawian and 54 USA families with teenage twins). Mean ± SEM values are plotted. The UniFrac matrix was permutated 1000 times; p values represent the fraction of times permuted differences were greater than real differences: ns (not significant; p>0.05), * p<0.05, **p<0.005.

Tanya Yatsunenko, et al. Nature. ;486(7402):222-227.
3.
Fig. 3

Fig. 3. Differences in the functional profiles of fecal microbiomes in the three study populations. From: Human gut microbiome viewed across age and geography.

Examples of KEGG ECs that exhibited the largest differences, as determined by Random Forests and ShotgunFuntionalizeR analyses, in proportional representation between USA and Malawian/Amerindian populations. Shown are the relative abundances of genes encoding the indicated ECs (normalized by Z-score across all datasets). (a) UPGMA clustering of 10 USA, 10 Malawian and 6 Amerindian baby fecal microbiomes. (b) UPGMA clustering of 16 USA, 5 Malawian and 5 Amerindian adult fecal microbiomes.

Tanya Yatsunenko, et al. Nature. ;486(7402):222-227.
4.
Fig. 1

Fig. 1. Differences in the fecal microbial communities of Malawians, Amerindians and residents of the USA at different ages. From: Human gut microbiome viewed across age and geography.

(a) UniFrac distances between children and adults decrease with increasing age of children in each population. Each point shows an average distance between a child and all adults unrelated to that child but from the same country. Results are derived from bacterial V4-16S rRNA datasets. (b) Large interpersonal variations are observed in the phylogenetic configurations of fecal microbial communities at early ages. Malawian and Amerindian children and adults are more similar to one another than to USA children and adults. UniFrac distances were defined from bacterial V4-16S rRNA data generated from the microbiota of 181 unrelated adults (≥18 years old) and 204 unrelated children (n=31 Malawians 0.03–3 years old, 21 3–17 years old; 30 Amerindians 0.08–3 years old, 29 3–17 years old; 31 residents of the USA 0.08–3 years old, 62 sampled at 3–17 years of age). Abbreviations: * p<0.05; **p<0.005 (Student’s t-test with 1000 Monte Carlo simulations). See Table S3 for a complete description of the statistical significance of all comparisons shown in the Figure. (c) PCoA of unweighted UniFrac distances for the fecal microbiota of adults.

Tanya Yatsunenko, et al. Nature. ;486(7402):222-227.

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