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Results: 4

1.
Figure 3

Figure 3. Proposed role of Cx43 in bone. From: CONNEXIN 43 AND BONE: NOT JUST A GAP JUNCTION PROTEIN.

Mounting evidence show that Cx43 is critical for the actions of pharmacologic, hormonal, and mechanical stimuli on bone cells (see text for details).

Lilian I. Plotkin. Actual osteol. ;7(2):79-90.
2.
Figure 2

Figure 2. Bisphosphonates actions in osteoclasts and osteoblasts/osteocytes. From: CONNEXIN 43 AND BONE: NOT JUST A GAP JUNCTION PROTEIN.

The anti-osteoporotic drugs bisphosphonates exert opposite actions on osteoclasts and osteoblast/osteocytes, by modulating distinct signaling pathways in these two cell types.

Lilian I. Plotkin. Actual osteol. ;7(2):79-90.
3.
Figure 3

Figure 3. Model for bisphosphonate action in osteoblasts and osteocytes. From: CONNEXIN 43 AND BONE: NOT JUST A GAP JUNCTION PROTEIN.

Bisphosphonates prevent osteoblast and osteocyte apoptosis by a novel mechanism that involves the phosphorylation of cytoplasmic targets of the kinases ERKs and is independent of new gene transcription.

Lilian I. Plotkin. Actual osteol. ;7(2):79-90.
4.
Figure 1

Figure 1. Hemichannels and gap junction channels formed by connexins. From: CONNEXIN 43 AND BONE: NOT JUST A GAP JUNCTION PROTEIN.

Cx43 is a transmembrane protein that forms hexamers on the cell membrane, known as hemichannels. Two hemichannels from opposing cells align to form a gap junction channel.

Lilian I. Plotkin. Actual osteol. ;7(2):79-90.

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