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Figure 1

Figure 1. From: Plasma proteomics of differential outcome to long-term therapy in children with idiopathic pulmonary arterial hypertension.

Proteomic analysis of long-term outcome response to vasodilator therapy. (A, upper image) Representative pseudocolored DIGE image showing separation of plasma proteins from responders and nonresponders. (Middle image) Representative spot map overlying a DIGE gel. Yellow spots indicate proteins common to both responders and nonresponder samples, while green and red spots highlight differential proteins. (Lower image) Representative spot-pick images for PON-1. (B, upper graph) Before and after therapy, serum amyloid A is significantly lower in responders than nonresponders. (Middle graph) There was no significant difference in serum amyloid P between responders and nonresponders, but SAP was significantly increased after therapy in responders (p = 0.043). (C) Plasma serum amyloid A is significantly increased in PAH patients (n = 31) versus controls (n = 11).

Michael E. Yeager, et al. Proteomics Clin Appl. 2012 June;6(5-6):257-267.

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