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Results: 7

1.
Figure 7

Figure 7. Reduced phosphorylation levels of Akt, ERK1/2 and STAT3 in LP hearts subjected to ischemia/reperfusion injury. From: Cardiac Vulnerability to Ischemia/Reperfusion Injury Drastically Increases in Late Pregnancy.

Representative immunoblots and Western Blot analysis of A. pAkt/Akt, B. pERK1/2/ERK1/2, C. pGSK3β/GSK3β and D. pSTAT3/STAT3 in heart homogenates subjected to ischemia/reperfusion from NP, LP and PP7, *p <0.05 LP vs. NP; #p<0.05 PP7 vs. LP; p >0.05 NP vs. PP7(n=4–7).

Jingyuan Li, et al. Basic Res Cardiol. 2012 July;107(4):271-271.
2.
Figure 1

Figure 1. The infarcts size is larger in LP rats subjected to ischemia/reperfusion injury than NP. From: Cardiac Vulnerability to Ischemia/Reperfusion Injury Drastically Increases in Late Pregnancy.

A. experimental protocol, the LAD was occluded in NP and LP rats for 45minutes followed by 3 hr of reperfusion. B. Representative heart cross sections of NP and LP rats. Percentage of area at risk (AAR) divided by LV (C), infarct size (IS) divided by AAR (D) and infarct size (IS) divided by LV (E). **p<0.01 vs. LP (n = 4–6).

Jingyuan Li, et al. Basic Res Cardiol. 2012 July;107(4):271-271.
3.
Figure 6

Figure 6. Increased cardiac ROS generation as well as mitochondrial superoxide production in late pregnant hearts subjected to ischemia/reperfusion. From: Cardiac Vulnerability to Ischemia/Reperfusion Injury Drastically Increases in Late Pregnancy.

A. Representative images of DHE staining of cardiac sections of NP, LP and PP7. B. Average fluorescence intensity in NP (black bar), LP (red bar) and PP7 (gray bar). C. Superoxide production in isolated mitochondria from NP, LP and PP7 using electron spin resonance, *p <0.05 LP vs. NP; #p<0.05 PP7 vs. LP; p >0.05 NP vs. PP7(n=4–5).

Jingyuan Li, et al. Basic Res Cardiol. 2012 July;107(4):271-271.
4.
Figure 2

Figure 2. Poor heart functional recovery of LP mice subjected to I/R injury restored 7 days postpartum. From: Cardiac Vulnerability to Ischemia/Reperfusion Injury Drastically Increases in Late Pregnancy.

Representatives of the left ventricular developed pressure (LVDP) and dP/dtMax and dP/dtMin as a function of time in NP (A), LP(B), PP1(C) and PP7(D). Rate Pressure Product (RPP)(E), LVDP (F) and dP/dtMax and dP/dtMin (G) as a function of time in NP(squares), LP(triangles), PP1(filled circles) and PP7(open circles). ** p < 0.01 vs. LP or PP1 in RPP,LVDP and dP/dtMax, # # p < 0.01 vs LP or PP1 in dP/dtMin (n = 6).

Jingyuan Li, et al. Basic Res Cardiol. 2012 July;107(4):271-271.
5.
Figure 3

Figure 3. Larger infarct size of isolated LP hearts subjected ischemia/reperfusion injury was fully reversed one week postpartum in mice. From: Cardiac Vulnerability to Ischemia/Reperfusion Injury Drastically Increases in Late Pregnancy.

A. Four slices of the same heart in each group after TTC staining. The white area represents the infarct zone and the red shows the viable area. B. The area of necrosis as the percentage of total ventricular area, **p <0.01 LP vs. NP; ##p<0.01 PP1 vs. LP; $$p<0.01 PP1 vs. LP; &p<0.05 PP1 vs. NP; ^ p<0.05 PP7 vs. PP1; p >0.05 NP vs. PP7(n=6).

Jingyuan Li, et al. Basic Res Cardiol. 2012 July;107(4):271-271.
6.
Figure 4

Figure 4. Mitochondrial respiration decreased in LP heart subjected to ischemia reperfusion injury. From: Cardiac Vulnerability to Ischemia/Reperfusion Injury Drastically Increases in Late Pregnancy.

A, D. Typical oxygen electrode traces showing the respiration in state 3 stimulated by 0.2 mM ADP (S3) and in resting state 4 (ADP-limited, S4) of complex-I in isolated mitochondria from NP, LP and PP7 subjected ischemia/reperfusion injury (A), or not subjected to ischemia/reperfusion injury (sham, D). B, E. Respiration rate of state 3 and state 4. and C, F. Respiratory control ratio (respiration rate of state 3/state 4) in NP, LP and PP7, **p <0.05 LP vs. NP; #p<0.05 PP7 vs. LP; p >0.05 NP vs. PP7(n=4).

Jingyuan Li, et al. Basic Res Cardiol. 2012 July;107(4):271-271.
7.
Fig. 5

Fig. 5. Lower threshold for triggering mPTP opening in response to calcium overload in LP compared to NP and PP7. From: Cardiac Vulnerability to Ischemia/Reperfusion Injury Drastically Increases in Late Pregnancy.

A. Typical recordings of the mPTP opening in isolated mitochondria from NP, LP and PP7 groups subjected to 20min of global ischemia followed by 10min of reperfusion. Twelve pulses (arrows) of 20 nmol calcium were required to trigger the opening of mPTP in NP compared to 7 pulses in LP and 14 pulses in PP7. B. Calcium retention capacity (CRC) in NP (white bar), LP (black bar) and PP7 (gray bar) subjected to ischemia/reperfusion injury. C. Typical recordings of the mPTP opening in isolated mitochondria from NP, LP and PP7 groups not subjected to ischemia/reperfusion injury. D. Calcium retention capacity (CRC) in NP (white bar), LP (black bar) and PP7 (gray bar) in mice not subjected to ischemia/reperfusion injury, **p <0.01 LP vs. NP; ##p<0.01 PP7 vs. LP; p >0.05 NP vs. PP7(n=6).

Jingyuan Li, et al. Basic Res Cardiol. 2012 July;107(4):271-271.

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