Results: 5

1.
Fig. 1

Fig. 1. From: Early Impact of Social Isolation and Breast Tumor Progression in Mice.

MB-231 Tumor Growth is Not Altered by Social Isolation Prior to Tumor Cell Injection. SCID female mice were singly housed seven days prior to orthotopic injection of MB-231 cells. Tumor diameter was measured with calipers on the days indicated. Tumor volume is expressed as mean ± SEM, n=8-10 mice per group.

Kelley S. Madden, et al. Brain Behav Immun. ;30(Suppl):S135-S141.
2.
Fig. 3

Fig. 3. From: Early Impact of Social Isolation and Breast Tumor Progression in Mice.

Social Isolation Reciprocally Alters Spleen NE (A) and Spleen Weight (B) Early After Social Isolation. A subset of mice described in Fig. 2 was sacrificed at day 3 post-separation. Results are expressed as mean ± SEM. n=5 mice per group. Asterisk indicates different versus group-housed at the corresponding time point by Newman-Keuls post-hoc analysis.

Kelley S. Madden, et al. Brain Behav Immun. ;30(Suppl):S135-S141.
3.
Fig. 4

Fig. 4. From: Early Impact of Social Isolation and Breast Tumor Progression in Mice.

Early Effects of Social Isolation on Spleen NE and Spleen Weight is Independent of Tumor Growth. Three days after transfer to single housing, SCID female mice were sacrificed and spleen NE (A), weight (B), and macrophage populations (C-E) were determined. Asterisk indicates significant difference by Student’s t-test, p<0.05. Results are expressed as mean ± SEM, n= 5 mice per group.

Kelley S. Madden, et al. Brain Behav Immun. ;30(Suppl):S135-S141.
4.
Fig. 2

Fig. 2. From: Early Impact of Social Isolation and Breast Tumor Progression in Mice.

MB-231 Tumor Growth is Transiently Increased by Social Isolation After Tumor Injection. SCID female were injected with MB-231 cells, and when all mice had palpable tumors, half of the mice were transferred from group to single housing. A. Tumor volume over time. NE (B) and human IL-6 (C) were measured by ELISA in tumors harvested at day 34 post separation. Results are expressed as mean ± SEM, n=8-9 mice per group. See text for statistical analysis of tumor growth. For tumor NE and human IL-6, no significant effects based on the non-parametric Mann-Whitney test, p = 0.1.

Kelley S. Madden, et al. Brain Behav Immun. ;30(Suppl):S135-S141.
5.
Fig. 5

Fig. 5. From: Early Impact of Social Isolation and Breast Tumor Progression in Mice.

Social Isolation Alters Tumor and Spleen Macrophage Populations. SCID female mice were injected with MB-231 in the mammary fat pad. When tumors were palpable, one-half the mice were transferred from group-housing to single housing. After 10 days, mice were sacrificed and tumor (A,B) and spleen (C,D) weight and NE concentration were determined, and macrophage populations were analyzed by flow cytometry in tumors (E-G) and spleens (H-J). Asterisk indicates significance based on the non-parametric Mann-Whitney test (A, B) or by student’s t-test (D), p<0.05. In (C), p = 0.067. The results are expressed as mean ± SEM of 9-10 mice per group.

Kelley S. Madden, et al. Brain Behav Immun. ;30(Suppl):S135-S141.

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