Figure 1

Figure 1. From: Clinical Development of Listeria monocytogenes-Based Immunotherapies.

Listeria monocytogenes (Lm)-based vaccines induce robust innate and adaptive immunity. Two key attributes contribute to Lm's potency: the ability to target CD8α+ DCs in vivo, and the intracellular localization and triggering of cytosolic NLRs and STING host cell PAMP sensors. (A) Upon intravenous administration the majority of live Lm are found within CD8α+ DCs that have been shown to be critical for the induction of antigen-specific T-cell responses in vivo. (B) The quality and magnitude of the induced T-cell response depends on the subcellular localization of Lm upon infection of the host antigen-presenting cell (APC). Lm strains that are able to escape from the phagolysosome into the cytosol of the APC (cytosolic Lm) induce robust T-cell immunity of high quality. Lm strains that remain in the phagolysosome fail to induce protective T-cell immunity, partly due to the MyD88-dependent induction of IL-10.

Dung T. Le, et al. Semin Oncol. ;39(3):311-322.

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