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Results: 5

1.
Figure 1

Figure 1. From: Neonatal Citalopram Treatment Inhibits the 5-HT Depleting Effects of MDMA Exposure in Rats.

Schematic of dosing schedule.

Tori L. Schaefer, et al. ACS Chem Neurosci. 2012 January 18;3(1):12-21.
2.
Figure 4

Figure 4. From: Neonatal Citalopram Treatment Inhibits the 5-HT Depleting Effects of MDMA Exposure in Rats.

P12, 16, and P21 5-HT levels: P12 groups were treated on P11, P16 groups were treated on P11–15, and P21 groups were treated on P11–20. (a) Main effect of treatment (F(3,21) = 39.03, p < 0.0001); (b) main effect of treatment (F(3,21) = 60.14, p < 0.0001); (c) main effect of treatment (F(9,53) = 6.80, p < 0.0001); (d) main effect of treatment (F(3,32) = 5.02, p < 0.009); (e) main effect of treatment (F(3,21) = 44.2, p < 0.0001); (f) main effect of treatment (F(3,18) = 10.34, p < 0.0003); (g) main effect of treatment (F(3,32) = 19.97, p < 0.0001); (h) main effect of treatment (F(3,21) = 8.03, p < 0.0009); (i) main effect of treatment (F(3,18) = 3.50, p < 0.04); n = 8/treatment/age/brain region. *p < 0.05 different from SAL+SAL; #p < 0.05 different from SAL+MDMA.

Tori L. Schaefer, et al. ACS Chem Neurosci. 2012 January 18;3(1):12-21.
3.
Figure 3

Figure 3. From: Neonatal Citalopram Treatment Inhibits the 5-HT Depleting Effects of MDMA Exposure in Rats.

P21 hippocampal 5-HT. SAL+MDMA significantly reduced 5-HT levels. None of the CIT+SAL groups showed changes compared with the SAL+SAL group. The 1 × 5 CIT+MDMA and 2 × 10 CIT+MDMA groups where higher than the SAL+MDMA group but significantly below the SAL+SAL group. However, the 2 × 5 and 1 × 10 CIT-MDMA groups were significantly higher than the SAL+MDMA group and not different from the SAL+SAL group. Main effect of treatment (F(9,53) = 6.8, p < 0.0001); n = 7/treatment. *p < 0.05 different from SAL+SAL; #p < 0.05 different from SAL+MDMA.

Tori L. Schaefer, et al. ACS Chem Neurosci. 2012 January 18;3(1):12-21.
4.
Figure 5

Figure 5. From: Neonatal Citalopram Treatment Inhibits the 5-HT Depleting Effects of MDMA Exposure in Rats.

5-HT levels at P60. Regional 5-HT levels in the (a) hippocampus, (b) entorhinal cortex (EC), and (c) neostriatum at P60 following P11–20 exposure. Both the SAL+MDMA and CIT+SAL groups had significantly decreased hippocampal 5-HT levels compared with the SAL+SAL group. No other effects were observed. (a) Main effect of treatment (F(3,21) = 4.39, p < 0.02), n = 8/treatment; (b) n = 8 for 2 × 5 CIT+SAL and n = 6 for other three treatment groups; (c) n = 8/treatment; *p < 0.05 different from SAL+SAL.

Tori L. Schaefer, et al. ACS Chem Neurosci. 2012 January 18;3(1):12-21.
5.
Figure 2

Figure 2. From: Neonatal Citalopram Treatment Inhibits the 5-HT Depleting Effects of MDMA Exposure in Rats.

Hippocampal 5-HT levels following (a) P11 and (b) P11–20 treatment and measured 24 h later at P12 and P21, respectively. (a) On P12, the SAL+MDMA group showed a >50% reduction in 5-HT levels. No significant changes were observed in any of the CIT+SAL groups. The three higher CIT+MDMA groups (CIT 2.5, 5, 10) showed nearly full protection from MDMA exposure, while the 1.25 CIT+MDMA showed a trend toward protection being midway between the SAL+MDMA and SAL+SAL groups. (b) Following P11–20 exposure, the SAL+MDMA-treated group showed even larger reductions of ∼70%. The CIT+MDMA group (CIT 2.5) showed no effects. The CIT+MDMA group showed an attenuation of the effects compared to SAL+MDMA but were still markedly reduced compared with the SAL+SAL group. (a) Main effect of treatment (F(9,63) = 6.86, p < 0.0001); n = 9 for 5 CIT+MDMA and 1.25 CIT+MDMA, n = 7 for 5 CIT+SAL and 1.25 CIT+MDMA; n = 8 for all other treatment groups. (b) Main effect of treatment (F(3,32) = 49.42, p < 0.0001); n = 5/treatment. *p < 0.05 different from SAL+SAL treatment; #p < 0.05 different from SAL+MDMA treatment.

Tori L. Schaefer, et al. ACS Chem Neurosci. 2012 January 18;3(1):12-21.

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