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1.
Figure 1

Figure 1. Connectivity with left anterior insula.. From: Resting-State Functional Connectivity between Fronto-Parietal and Default Mode Networks in Obsessive-Compulsive Disorder.

a) OCD patients exhibited greater connectivity than controls between the left anterior insula seed and default mode network regions including parahippocampus, posterior cingulate cortex (PCC)/precuneus, posterior inferior parietal lobule (pIPL), and dorsomedial prefrontal cortex (DMPFC). Patients also showed greater connectivity with pre-postcentral gyrus. Numbers above images represent z-coordinate (MNI format) of axial slices. Images displayed at p<.005, corrected across whole-brain gray matter at p<.05, b) Connectivity maps with left anterior insula for both groups, displayed at p<.005 with 10 contiguous voxels. Black circles represent location of seed. Color bars represent t-scores.

Emily R. Stern, et al. PLoS One. 2012;7(5):e36356.
2.
Figure 2

Figure 2. Connectivity with right anterior insula.. From: Resting-State Functional Connectivity between Fronto-Parietal and Default Mode Networks in Obsessive-Compulsive Disorder.

a) OCD patients exhibited greater connectivity than controls between the right anterior insula seed and default mode network regions including posterior cingulate cortex (PCC)/precuneus, dorsomedial prefrontal cortex (DMPFC)/anterior medial frontal cortex (aMFC), posterior inferior parietal lobule (pIPL), and parahippocampus. Patients also showed greater connectivity with right posterior insula and bilateral thalamus. Images displayed at p<.005, corrected across whole-brain gray matter at p<.05, b) Connectivity maps with right anterior insula seed for both groups, displayed at p<.005 with 10 contiguous voxels. Black circles represent location of seed, c) Extracted connectivity values (y-axes show z-transformed correlation coefficients) in DMPFC/aMFC, rostral PCC/precuneus, right posterior insula, and right thalamus for unmedicated OCD patients (uOCD), medicated OCD patients (mOCD), unmedicated healthy controls (uHC), and medicated patient controls (mPC); uOCD>uHC and mOCD>mPC for all regions shown at p<.05 in multiple regressions controlling for generalized anxiety/depression and education (see File S1 and Table S2). Error bars represent standard error of the mean. Color bars represent t-scores. Coordinates are in MNI format.

Emily R. Stern, et al. PLoS One. 2012;7(5):e36356.

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