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1.
Figure 2

Figure 2. From: Morphine-induced conditioned place preference and associated behavioural plasticity in HIV-1 transgenic rats.

Time spent in the morphine-paired and saline-paired side of the CPP apparatus by strain and by color of morphine-paired chamber, in preconditioning and post-conditioning phase is shown.

Natasha F Homji, et al. Int J Clin Exp Med. 2012;5(2):105-123.
2.
Figure 3

Figure 3. From: Morphine-induced conditioned place preference and associated behavioural plasticity in HIV-1 transgenic rats.

Time spent in the morphine-paired and saline-paired side of the CPP apparatus by strain and by color of morphine-paired chamber separated into three 5-minute time segments, in preconditioning and post-conditioning phase is shown.

Natasha F Homji, et al. Int J Clin Exp Med. 2012;5(2):105-123.
3.
Figure 10

Figure 10. From: Morphine-induced conditioned place preference and associated behavioural plasticity in HIV-1 transgenic rats.

Time in Morphine-paired chamber over time segments for HIV-1Tg rats given three additional days of extinction during the second extinction phase (Mean of Days 18-20).

Natasha F Homji, et al. Int J Clin Exp Med. 2012;5(2):105-123.
4.
Figure 1

Figure 1. From: Morphine-induced conditioned place preference and associated behavioural plasticity in HIV-1 transgenic rats.

Time spent in the morphine-paired and saline-paired side of the CPP apparatus by strain in preconditioning and post-conditioning phase is shown. On post-conditioning day animals were conditioned daily for 15 minutes following a 3.5 mg/kg morphine (i.p.) dose every other day for 6 days. The following day after 6 conditioning sessions, animals were given free access to entire apparatus and tested for CPP.

Natasha F Homji, et al. Int J Clin Exp Med. 2012;5(2):105-123.
5.
Figure 5

Figure 5. From: Morphine-induced conditioned place preference and associated behavioural plasticity in HIV-1 transgenic rats.

Spontaneous Recovery Score- The time spent on the morphine-paired side during the fourth time segment (minutes 16-20) was subtracted from the time spent on the morphine-paired side during third time segment (minutes 11-15). A positive score indicates spontaneous recovery, whereas a negative score indicates continued habituation. The results for the white-morphine paired and black-morphine paired HIV-1 and F344 groups averaged across days for the two extinctions sessions are shown. To facilitate statistical analysis of Extinction 1 (which had 8 days) and Extinction 2 (which had 9 days), the last day of extinction 2 was omitted.

Natasha F Homji, et al. Int J Clin Exp Med. 2012;5(2):105-123.
6.
Figure 7

Figure 7. From: Morphine-induced conditioned place preference and associated behavioural plasticity in HIV-1 transgenic rats.

The time spent in the morphine- and saline-paired sides over days of the HIV-1Tg animals that received morphine paired with the white side. The Extinction 1 graphs are shown on the left side and Extinction 2 are shown on the right. Data from only 2 of the 6 time segments are shown. The top graphs show the first time segment (minutes 1- 5) and the lower graphs show the fourth time segment (minutes 16-20). During Extinction 2 the 16-20 minute time segment was preceded by a break from the previous session to allow for spontaneous recovery of exploratory behaviour.

Natasha F Homji, et al. Int J Clin Exp Med. 2012;5(2):105-123.
7.
Figure 9

Figure 9. From: Morphine-induced conditioned place preference and associated behavioural plasticity in HIV-1 transgenic rats.

The time spent in the morphine- and saline-paired sides over days of the HIV-1Tg animals that received morphine paired with the black side. The Extinction 1 graphs are shown on the left side and Extinction 2 are shown on the right. Data from only 2 of the 6 time segments are shown. The top graphs show the first time segment (minutes 1- 5) and the lower graphs show the fourth time segment (minutes 16-20). During Extinction 2 the 16-20 minute time segment was preceded by a break from the previous session to allow for spontaneous recovery of exploratory behaviour.

Natasha F Homji, et al. Int J Clin Exp Med. 2012;5(2):105-123.
8.
Figure 8

Figure 8. From: Morphine-induced conditioned place preference and associated behavioural plasticity in HIV-1 transgenic rats.

The time spent in the morphine- and saline-paired sides over days of the F344 animals that received morphine paired with the black side. The Extinction 1 graphs are shown on the left side and Extinction 2 are shown on the right. Data from only 2 of the 6 time segments are shown. The top graphs show the first time segment (minutes 1- 5) and the lower graphs show the fourth time segment (minutes 16-20). During Extinction 2 the 16-20 minute time segment was preceded by a break from the previous session to allow for spontaneous recovery of exploratory behaviour.

Natasha F Homji, et al. Int J Clin Exp Med. 2012;5(2):105-123.
9.
Figure 6

Figure 6. From: Morphine-induced conditioned place preference and associated behavioural plasticity in HIV-1 transgenic rats.

The time spent in the morphine- and saline-paired sides over days of the F344 animals that received morphine paired with the white side. The Extinction 1 graphs are shown on the left side and Extinction 2 are shown on the right. Data from only 2 of the 6 time segments are shown The top graphs show the first time segment (minutes 1- 5) and the lower graphs show the fourth time segment (minutes 16-20). During Extinction 2 the 16-20 minute time segment was preceded by a break from the previous session to allow for spontaneous recovery of exploratory behavior.

Natasha F Homji, et al. Int J Clin Exp Med. 2012;5(2):105-123.
10.
Figure 4

Figure 4. From: Morphine-induced conditioned place preference and associated behavioural plasticity in HIV-1 transgenic rats.

Extinction phase: To test for extinction, animals [F344 (n=14), HIV-1Tg (n=14)] were given free access to the entire apparatus for 30 mins (F344: 8 days, HIV-1Tg: 8 days) every day (Extinction 1) and then for 2 fifteen min sessions/day (F344:9 days, HIV-1Tg: 13 days) (Extinction 2A and 2B) until all animals reach extinction. Average time spent in the morphine-paired side by strain and by color of morphine-paired chamber separated into three 5- minute time segments (group means) in the 2 phases of extinction [Extinction 1 and Extinction 2 (A and B)] is shown.

Natasha F Homji, et al. Int J Clin Exp Med. 2012;5(2):105-123.

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