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Results: 5

1.
Figure 2

Figure 2. From: Synthesis and Structure-Activity Relationship Studies of HIV-1 Virion Infectivity Factor (Vif) Inhibitors that Block Viral Replication.

a) A convergent route for the synthesis of RN18 and analogues; b) alternate route for the synthesis of RN18 and C-ring analogues.

Akbar Ali, et al. ChemMedChem. ;7(7):1217-1229.
3.
Scheme 1

Scheme 1. From: Synthesis and Structure-Activity Relationship Studies of HIV-1 Virion Infectivity Factor (Vif) Inhibitors that Block Viral Replication.

Reagents and conditions: a) Cu(I)I, K2CO3, iPrOH, HOCH2CH2OH, MW (150 WT), 80 °C, 30 min (2 ×); b) SnCl2∙2H2O, EtOAc, 80 °C, 3 h.

Akbar Ali, et al. ChemMedChem. ;7(7):1217-1229.
4.
Scheme 5

Scheme 5. From: Synthesis and Structure-Activity Relationship Studies of HIV-1 Virion Infectivity Factor (Vif) Inhibitors that Block Viral Replication.

Reagents and conditions: (a) Cu(I)Cl, Cs2CO3, CH2(Cot-Bu)2, NMP, MW (150 WT), 120 °C, 30 min (2 ×); b) Cu(OAc)2, CH2Cl2, PhOH, Et3N, 4A MS, RT, overnight; c) K2CO3, DMF, MW (150 WT), 90 °C, 30 min (2 ×).

Akbar Ali, et al. ChemMedChem. ;7(7):1217-1229.
5.
Scheme 2

Scheme 2. From: Synthesis and Structure-Activity Relationship Studies of HIV-1 Virion Infectivity Factor (Vif) Inhibitors that Block Viral Replication.

Reagents and conditions: a) Cu(I)I, K2CO3, 1,2-DME, MW (150 WT), 80 °C, 30 min (2 ×); (b) Ba(OH)2∙8H2O, MeOH, 80 °C, 2 h; (c) (i) (COCl)2, CH2Cl2, DMF, RT, 8 h, (ii) R′R″NH (14a–h), Et3N, CH2Cl2, 0 °C to RT, overnight; d) SnCl2∙2H2O, EtOAc, 80 °C, 3 h.

Akbar Ali, et al. ChemMedChem. ;7(7):1217-1229.

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