Results: 5

1.
Figure 2

Figure 2. Maximum likelihood trees of intra-host HBV variants from six patients.. From: Convergence and coevolution of Hepatitis B virus drug resistance.

HBV populations sampled from patients infected with genotypes A (n=4), D (n=1), G (n=1) before (open circles) and after (colour-filled circles) lamivudine treatment. Each colour presents a single patient.

Hong Thai, et al. Nat Commun. 2012 April 17;3:789.
2.
Figure 4

Figure 4. Scatterplot of distances among intra-host HBV variants of six patients.. From: Convergence and coevolution of Hepatitis B virus drug resistance.

Genetic distances are shown for Patients 6–11. Each pre-lamivudine sequence was plotted according to its value in two dimensions: the average distance to all other pre-treatment variants (x axis) and the average distance to all other post-treatment variants (y axis).

Hong Thai, et al. Nat Commun. 2012 April 17;3:789.
3.
Figure 3

Figure 3. Maximum likelihood trees of intra-host HBV variants sampled before and after lamivudine therapy.. From: Convergence and coevolution of Hepatitis B virus drug resistance.

HBV variants were sampled from Patients 6–11 before (blue) and after (red) treatment with lamivudine. The node size is proportional to frequency of the corresponding variant in the viral population. For Patients 8 and 9, only pre-treatment subpopulations that were genetically closest to the resistant variants are shown.

Hong Thai, et al. Nat Commun. 2012 April 17;3:789.
4.
Figure 5

Figure 5. BNs of intra-host HBV variants from Patients 6–11.. From: Convergence and coevolution of Hepatitis B virus drug resistance.

Tp, spacer, rt and rh—terminal protein, spacer, RT and RNAse H domains of the HBV P protein; S1, S2 and hepatitis B surface antigen (HBsAg)—preS1, preS2 and S domains of the HBV S protein; X, the X protein; hepatitis B core antigen (HBcAg), the core protein; TS, sampling time, the variable describing sampling of HBV variants before or after lamivudine treatment.

Hong Thai, et al. Nat Commun. 2012 April 17;3:789.
5.
Figure 1

Figure 1. Maximum likelihood trees of intra-host HBV variants sampled from patients after lamivudine treatment.. From: Convergence and coevolution of Hepatitis B virus drug resistance.

The node size is proportional to frequency of the corresponding variant in the viral population. Colours correspond to the codon states at position rt204: rtM204I coded by ATT or ATC is shown in red or grey, respectively; rtM204V is shown in blue (codon GTG); the wild type is shown in cyan (codon ATG). The distance between the two genotype clusters of Patient 1 was plotted 20 times shorter to allow the visualization of minor variants.

Hong Thai, et al. Nat Commun. 2012 April 17;3:789.

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