Results: 3

1.
Figure 2

Figure 2. SNPs in the HLA region.. From: Novel Associations for Hypothyroidism Include Known Autoimmune Risk Loci.

(A) shows statistics for the main GWAS, (B) shows statistics conditioned on 5 genome-wide significant SNPs (rs925489, rs6679677, rs3184504, rs4915077, rs2517532). For details, see Figure 1.

Nicholas Eriksson, et al. PLoS One. 2012;7(4):e34442.
2.
Figure 3

Figure 3. Summary of results.. From: Novel Associations for Hypothyroidism Include Known Autoimmune Risk Loci.

Regions associated with hypothyroidism classified by signficance level (genome-wide or suggestive), known function (thyroid versus autoimmune), and whether they had previously been associated with hypothyroidism.

Nicholas Eriksson, et al. PLoS One. 2012;7(4):e34442.
3.
Figure 1

Figure 1. SNPs in the VAV3 region.. From: Novel Associations for Hypothyroidism Include Known Autoimmune Risk Loci.

In the plot, circles represent unannotated SNPs, upside-down triangles represent non-synonymous variants, and boxes with an “x” are SNPs in regions that are highly conserved across 44 placental mammals. Colors depict the squared correlation () of each SNP with the most associated SNP (i.e., rs4915077, shown in purple). Gray indicates SNPs for which information was missing. Plots were produced using the LocusZoom program [50].

Nicholas Eriksson, et al. PLoS One. 2012;7(4):e34442.

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