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Fig. 1.

Fig. 1. From: The CFTR and ENaC debate: how important is ENaC in CF lung disease?.

Schematic illustration of mouse and human lower airways. Note the cellular diversity of the epithelial cell types lining the airways and submucosal glands. Clara cells are present throughout the lower airway epithelia in mice. Submucosal (mixed serous and mucous) glands are only found in the proximal trachea in mice. The number of Clara cells increases in the bronchiole. Submucosal glands are present throughout the cartilaginous airways (trachea, bronchi) in the human airways and Clara cells only appear in bronchioles. In the alveoli, type I and type II alveolar epithelial cells (AEC) are present both in mouse and human. Type I AECs provide majority of the alveoli lining surface and type II cells secrete surfactant. The β-ENaC and the hCFTR+β-ENaC mice were developed by using a Clara cell-specific promoter to express β-ENaC or hCFTR+β-ENaC only in Clara cells. The architecture of the porcine airways is similar to human with submucosal, mixed glands throughout the cartilaginous airways.

James F. Collawn, et al. Am J Physiol Lung Cell Mol Physiol. 2012 June 1;302(11):L1141-L1146.

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