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Results: 4

1.
Figure 4

Figure 4. From: Nanocytology of rectal colonocytes to assess risk of colon cancer based on field cancerization.

depicts that Ld from rectal colonocytes is equally sensitive to both, the patients having proximal lesions (n = 19) and distal lesions (n =16) of size > 5mm with a non-significant P-value ∼ 0.15.

Dhwanil Damania, et al. Cancer Res. ;72(11):2720-2727.
2.
Figure 3

Figure 3. shows the diagnostic performance of the single parameter, disorder strength (Ld) for various risk-groups.. From: Nanocytology of rectal colonocytes to assess risk of colon cancer based on field cancerization.

The performance is excellent for the advanced adenoma patients with AUROC of 0.85, and it improves with AUROC of 0.89 and 0.92 for patients with HNPCC and frank cancer respectively.

Dhwanil Damania, et al. Cancer Res. ;72(11):2720-2727.
3.
Figure 2

Figure 2. Results obtained from N = 146 patients using PWS microscopy. From: Nanocytology of rectal colonocytes to assess risk of colon cancer based on field cancerization.

demonstrates that PWS measured disorder strength (Ld) parallels the increasing risk of developing colorectal cancer for patients harboring different size of precancerous lesions (non-diminutive adenoma) in their colon, having specific genetic mutation leading to Lynch syndrome (HNPCC) and frank cancers.

Dhwanil Damania, et al. Cancer Res. ;72(11):2720-2727.
4.
Figure 1

Figure 1. Representative rectal colonocytes from control and cancer patients. From: Nanocytology of rectal colonocytes to assess risk of colon cancer based on field cancerization.

(a) and (b) are the H & E stained microscopic images of rectal epithelium from control and cancer patient respectively. (c), (d), (e) are representative PWS generated pseudocolor heat-map of Ld for the colonocytes from the circled region of control patient and similarly (f), (g), (h) are for cancer patient. Although the microscopic images of the colonocytes from the control and cancer patient are indistinguishable, the disorder strength (Ld) was markedly increased in cancer patients compared to the control.

Dhwanil Damania, et al. Cancer Res. ;72(11):2720-2727.

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