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Results: 5

1.
Figure 5

Figure 5. From: A clustering-based method to detect functional connectivity differences.

Connectivity index calculated using the leave-one-out procedure. The connectivity indices of the aMCI group are significantly lower than those of the CN group (p<0.013).

Gang Chen, et al. Neuroimage. ;61(1):56-61.
2.
Figure 3

Figure 3. From: A clustering-based method to detect functional connectivity differences.

The clustering method identified three clusters, using group difference information. (A) The posterior cingulate cluster. (B) The thalamus cluster. (C) The retrosplenial cingulate cluster.

Gang Chen, et al. Neuroimage. ;61(1):56-61.
3.
Figure 4

Figure 4. From: A clustering-based method to detect functional connectivity differences.

Decreased connectivity to the three clusters shown in Figure 3. (A) The posterior cingulate cluster. (B) The thalamus cluster. (C) The retrosplenial cingulate cluster. Color bar indicates the percentage of disconnection. For example, light blue indicates that a voxel is disconnected to 75% to 100% of the voxels in the corresponding cluster.

Gang Chen, et al. Neuroimage. ;61(1):56-61.
4.
Figure 2

Figure 2. From: A clustering-based method to detect functional connectivity differences.

Cluster size threshold (mean ± standard deviation) at 5% false positive discovery rate over the nine homogeneity thresholds considered. The individual cluster size threshold was set so that there is a less than 5% chance (corrected) to identify a cluster that satisfies all of the following conditions in randomly grouped subjects: 1) the voxels in the cluster were all spatially connected; 2) the number of voxels in the cluster was more than the cluster size threshold; 3) the homogeneity index of the cluster was above the corresponding homogeneity threshold.

Gang Chen, et al. Neuroimage. ;61(1):56-61.
5.
Figure 1

Figure 1. From: A clustering-based method to detect functional connectivity differences.

Graphical demonstration of the clustering method. (A) Illustration of r-matrices of four subjects and the thresholded Z-matrix comparing 17 aMCI subjects and 22 CN subjects. The thresholded Z-matrices have dimensions of 4442x4442 corresponding to 4442 voxels of the brain in Talairach space. (B) The hierarchical relationship of the 4442 voxels. The relationship was calculated using the similarity of each voxel’s thresholded Z-values. (C) The hierarchical relationship among 93 voxels zoomed in from Fig B. These voxels satisfy homogeneity criteria and cluster size criteria. The numbers below the dendrogram represent the 93 voxels’ indices ordered by their spatial locations. Note all voxels in the cluster are descendants of one ancestor node. (D) The 93 voxels overlaid on a brain image in Talairach space (left). Based on the anatomical location, the cluster is named the “posterior cingulate cluster.” The Z-matrix of the posterior cingulate cluster is illustrated on the right (size 93x4442). Note the high similarity of the Z-values.

Gang Chen, et al. Neuroimage. ;61(1):56-61.

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