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1.
Fig. (3)

Fig. (3). From: Current Advances in Detection and Treatment of Babesiosis.

Chemical structures of current and novel drugs against babesiosis.

J Mosqueda, et al. Curr Med Chem. 2012 April;19(10):1504-1518.
2.
Fig. (2)

Fig. (2). From: Current Advances in Detection and Treatment of Babesiosis.

Babesia especies in various hosts and tissues. A) Babesia bigemina in bovine erythrocytes. Blood smear stained with Giemsa. B) Babesia bovis in bovine erythrocytes. Blood smear stained with Giemsa. C) Babesia microti in mouse erytrocytes. Blood smear stained with Giemsa. D) Babesia bigemina kinetes in Rhipicephalus (Boophilus) microplus haemolymph. Haemolymph smear stained with Giemsa. E) Babesia bovis in a bovine brain capillar. Histological section of brain tissue stained with Giemsa. F) Detection of antibodies against Babesia bigemina by the Indirect Fluorescent Antibody Test (IFAT). Bovine antibodies were detected by a secondary, donkey IgG anti- bovine IgG bound to Alexa-Fluor 488. Images were obtained with an objective of 100X.

J Mosqueda, et al. Curr Med Chem. 2012 April;19(10):1504-1518.
3.
Fig. (1)

Fig. (1). From: Current Advances in Detection and Treatment of Babesiosis.

The life cycle of Babesia bovis.
A. A B. bovis sporozoite invades an erythrocyte and transforms into a trofozoite.
B. The trofozoite in a ring shape.
C. Two merozoites are generated from each trofozoite by binary fission.
D. Merozoites are initially bound together resembling two pears in an acute angle.
E. The mature merozoites separate before escaping the erythrocyte.
F. Merozoites are liberated from the erythrocyte. Some of them will invade new erythrocytes and develop into trofozoites, while others will be picked up by adult ticks to continue their cycle in the invertebrate host.
G. Sexual stages are freed from the red blood cells in the intestinal tick lumen and develop to gametocytes.
H. The gametocytes transform into male and female gametes that form a zygote after fusion.
I. The zygote develops into an infecting stage and penetrates the tick intestinal cells.
J. Fission bodies form and from them motile kinetes develop.
K. Kinetes destroy the intestinal cells, escape into the haemolymph and distribute into the different cell types and tissues, including the ovaries.
L. In the ovary, embryo cells are infected by kinetes (transovarial transmission).
M. When the female tick lays her eggs, the embryos are already infected.
N. Hatched infected larvae attach to a bovine and the kinetes migrate to the salivary glands of the tick, where they form a sporoblast.
O. Thousands of sporozoites develop from each sporoblast.
P. Tick larvae feed from the bovine blood and the sporozoites are liberated with saliva into the animal’s circulatory system.

J Mosqueda, et al. Curr Med Chem. 2012 April;19(10):1504-1518.

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