Results: 3

1.
Figure 3

Figure 3. From: Chronic Cocaine Exposure During Pregnancy Increases Postpartum Neuroendocrine Stress Responses.

CC-treated dams (Type 1 and Type 2) were immobile for a shorter duration (F (1,22) = 5.771, p≤ 0.05, see Figure 3A) compared to UN dams. Experimental procedure type also influenced FST behaviour. Type 1 dams were immobile less often (F (1,22) = 9.295, p≤ 0.01) and for a shorter duration (F (1, 22) = 9.672, p≤ 0.01) compared to Type 2 dams, regardless of treatment.

Sarah K. Williams, et al. J Neuroendocrinol. ;24(4):701-711.
2.
Figure 2

Figure 2. From: Chronic Cocaine Exposure During Pregnancy Increases Postpartum Neuroendocrine Stress Responses.

At baseline (morning), CC-treated dams showed a non-significant trend for lower CORT concentrations compared to UN dams (z=1.753, p≤ 0.08). Type 1 UN dams did not exhibit a change in CORT concentrations following the OFT (Figure 2A); however, CC-treated dams showed a significant increase (z= 2.073, p≤ 0.05). Type 3 dams were tested for CORT concentrations at corresponding times of day but without having performed the behavioural tests and there were no differences between treatment groups or within groups between the two time points (Figure 2B).

Sarah K. Williams, et al. J Neuroendocrinol. ;24(4):701-711.
3.
Figure 1

Figure 1. From: Chronic Cocaine Exposure During Pregnancy Increases Postpartum Neuroendocrine Stress Responses.

Analyses indicated no significant differences between cohorts on a number of behavioural variables including centre duration, centre frequency, centre distance travelled or velocity. See Table 2 for individual cohort comparisons. Gestational drug treatment and type were randomly assigned, and a 2-way ANOVA revealed there were no significant differences in the baseline centre duration or locomotor activity between treatment or behavioural test types (see Figure 1 A,B).

Sarah K. Williams, et al. J Neuroendocrinol. ;24(4):701-711.

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